Prevalence of human papillomavirus genotypes in women from a rural region of Puebla, Mexico.

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Tytuł:: Prevalence of human papillomavirus genotypes in women from a rural region of Puebla, Mexico.
Autorzy:: Velázquez-Márquez N; Laboratorio de Biología Molecular y Virología, Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social, Km 4.5 Carretera Federal Atlixco-Metepec, 74360 Metepec, Puebla, Mexico.
Paredes-Tello MA
Pérez-Terrón H
Santos-López G
Reyes-Leyva J
Vallejo-Ruiz V
Źródło:: International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases [Int J Infect Dis] 2009 Nov; Vol. 13 (6), pp. 690-5. Date of Electronic Publication: 2009 Jan 14.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Publication: Hamilton, ON : Elsevier
Original Publication: Hamilton, ON : Decker, c1996-
MeSH Terms:: Alphapapillomavirus*/classification
Alphapapillomavirus*/genetics
Alphapapillomavirus*/isolation & purification
Rural Population*
Papillomavirus Infections/*epidemiology
Adolescent ; Adult ; Cervix Uteri/virology ; Cross-Sectional Studies ; DNA, Viral/analysis ; Female ; Genotype ; Humans ; Mexico/epidemiology ; Middle Aged ; Papillomavirus Infections/virology ; Prevalence ; Risk Factors ; Surveys and Questionnaires ; Uterine Cervical Neoplasms/epidemiology ; Uterine Cervical Neoplasms/virology ; Vaginal Smears ; Young Adult ; Uterine Cervical Dysplasia/epidemiology ; Uterine Cervical Dysplasia/virology
Substance Nomenclature:: 0 (DNA, Viral)
Entry Date(s):: Date Created: 20090117 Date Completed: 20100127 Latest Revision: 20221207
Update Code:: 20240104
DOI:: 10.1016/j.ijid.2008.10.010
PMID:: 19147384
: Czasopismo naukowe

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Objective: To determine the prevalence of human papillomavirus (HPV) genotypes 6, 11, 16, 18, and 31 in Mexican women living in rural areas of Puebla, Mexico and to evaluate risk factors associated with cervical neoplasm in this population.
Methods: A cross-sectional study was conducted in 326 women at the General Hospital of Metepec, Puebla. Cervical samples were obtained using a cytobrush and tested for HPV genotypes by PCR assays using type-specific primers. A questionnaire was completed regarding gynecological, obstetric, and sexual behavior of the patients.
Results: The overall prevalence of HPV infection was 25.4%, with two peaks of higher HPV prevalence in those aged 18-24 and 55-64 years. The individual genotype prevalences were: 9.6% HPV6, 4.8% HPV11, 54.2% HPV16, 37.3% HPV18, and 9.6% HPV31. Number of pregnancies was the most important risk factor associated with cervical cancer.
Conclusions: HPV16 was the most common type found in all cervical lesions. Genotype 16 or 18 was detected in patients with a diagnosis of cervical cancer. We found two peaks of age-specific HPV prevalence similar to findings reported worldwide.

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