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Tytuł pozycji:

Transglutaminases in inflammation and fibrosis of the gastrointestinal tract and the liver.

Tytuł:
Transglutaminases in inflammation and fibrosis of the gastrointestinal tract and the liver.
Autorzy:
Elli L; Center for Prevention and Diagnosis of Celiac Disease, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, via F. Sforza, Milan, Italy. />Bergamini CM
Bardella MT
Schuppan D
Źródło:
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver [Dig Liver Dis] 2009 Aug; Vol. 41 (8), pp. 541-50. Date of Electronic Publication: 2009 Feb 04.
Typ publikacji:
Journal Article; Review
Język:
English
Imprint Name(s):
Publication: 2003- : Amsterdam : Elsevier
Original Publication: Roma, Italy : Editrice gastroenterologica italiana, c2000-
MeSH Terms:
Gastrointestinal Diseases/*physiopathology
Liver Diseases/*physiopathology
Transglutaminases/*physiology
Apoptosis/physiology ; Celiac Disease/physiopathology ; Enzyme Activation ; Fibrosis ; GTP-Binding Proteins/chemistry ; GTP-Binding Proteins/physiology ; Humans ; Inflammation ; Inflammatory Bowel Diseases/physiopathology ; Protein Glutamine gamma Glutamyltransferase 2 ; Transglutaminases/chemistry
Liczba referencji:
158
Substance Nomenclature:
EC 2.3.2.13 (Protein Glutamine gamma Glutamyltransferase 2)
EC 2.3.2.13 (Transglutaminases)
EC 3.6.1.- (GTP-Binding Proteins)
Entry Date(s):
Date Created: 20090207 Date Completed: 20091002 Latest Revision: 20211203
Update Code:
20240104
DOI:
10.1016/j.dld.2008.12.095
PMID:
19195940
Czasopismo naukowe
Transglutaminases are a family of eight currently known calcium-dependent enzymes that catalyze the cross-linking or deamidation of proteins. They are involved in important biological processes such as wound healing, tissue repair, fibrogenesis, apoptosis, inflammation and cell-cycle control. Therefore, they play important roles in the pathomechanisms of autoimmune, inflammatory and degenerative diseases, many of which affect the gastrointestinal system. Transglutaminase 2 is prominent, since it is central to the pathogenesis of celiac disease, and modulates inflammation and fibrosis in inflammatory bowel and chronic liver diseases. This review highlights our present understanding of transglutaminase function in gastrointestinal and liver diseases and therapeutic strategies that target transglutaminase activities.

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