Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Tytuł pozycji:

A tandem triplication, trp(1)(q21q32), in a patient with follicular lymphoma: a case study and review of the literature.

Tytuł:
A tandem triplication, trp(1)(q21q32), in a patient with follicular lymphoma: a case study and review of the literature.
Autorzy:
Park TS; Department of Laboratory Medicine, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun-gu, Seoul, 120-752, Korea.
Lee ST
Song J
Lee KA
Kim J
Kim SJ
Lee JH
Song S
Choi JR
Źródło:
Cancer genetics and cytogenetics [Cancer Genet Cytogenet] 2009 Mar; Vol. 189 (2), pp. 127-31.
Typ publikacji:
Case Reports; Journal Article; Review
Język:
English
Imprint Name(s):
Original Publication: [New York] Elsevier/North-Holland.
MeSH Terms:
Chromosomes, Human, Pair 1*
Tandem Repeat Sequences*
Lymphoma, Follicular/*genetics
Aged ; Cytogenetic Analysis ; Gene Duplication ; Humans ; Male ; Trisomy
Liczba referencji:
30
Entry Date(s):
Date Created: 20090214 Date Completed: 20090220 Latest Revision: 20090213
Update Code:
20240104
DOI:
10.1016/j.cancergencyto.2008.11.005
PMID:
19215795
Czasopismo naukowe
A 1q triplication is a rare karyotypic event in hematologic malignancies, with 26 cases of 1q triplication reported in the literature. Although 1q duplication or triplication is present with a high incidence in Burkitt lymphoma and Fanconi anemia, there have been no detailed reports of an association between non-Burkitt type lymphomas and 1q triplication. Presented here is the case of a 69-year-old man with follicular lymphoma (FL) and 1q triplication, with a review of the pertinent literature. The patient was diagnosed with FL with bone marrow involvement; his bone marrow chromosome study revealed 50,XY,trp(1)(q21q32),+3,+add(3)(q21),+7,+9,add(13)(p11.2)[11]/51 approximately 52,idem,+19,+22[8]/46,XY[3]. Review of the Mitelman Database of Chromosome Aberrations in Cancer revealed 7 previous cases of non-Burkitt type lymphoma (including FL) with 1q triplication. On the basis of these eight cases, we conclude that 1q triplication represents a rare secondary genetic event with prognostic significance in patients with FL or other non-Burkitt types of lymphoma. Further studies are needed to investigate these rare 1q triplication in hematologic malignancies.

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies