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Tytuł:
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A tandem triplication, trp(1)(q21q32), in a patient with follicular lymphoma: a case study and review of the literature.
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Autorzy:
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Park TS; Department of Laboratory Medicine, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun-gu, Seoul, 120-752, Korea.
Lee ST
Song J
Lee KA
Kim J
Kim SJ
Lee JH
Song S
Choi JR
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Źródło:
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Cancer genetics and cytogenetics [Cancer Genet Cytogenet] 2009 Mar; Vol. 189 (2), pp. 127-31.
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Typ publikacji:
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Case Reports; Journal Article; Review
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Język:
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English
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Imprint Name(s):
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Original Publication: [New York] Elsevier/North-Holland.
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MeSH Terms:
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Chromosomes, Human, Pair 1*
Tandem Repeat Sequences*
Lymphoma, Follicular/*genetics
Aged ; Cytogenetic Analysis ; Gene Duplication ; Humans ; Male ; Trisomy
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Liczba referencji:
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30
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Entry Date(s):
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Date Created: 20090214 Date Completed: 20090220 Latest Revision: 20090213
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Update Code:
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20240104
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DOI:
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10.1016/j.cancergencyto.2008.11.005
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PMID:
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19215795
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A 1q triplication is a rare karyotypic event in hematologic malignancies, with 26 cases of 1q triplication reported in the literature. Although 1q duplication or triplication is present with a high incidence in Burkitt lymphoma and Fanconi anemia, there have been no detailed reports of an association between non-Burkitt type lymphomas and 1q triplication. Presented here is the case of a 69-year-old man with follicular lymphoma (FL) and 1q triplication, with a review of the pertinent literature. The patient was diagnosed with FL with bone marrow involvement; his bone marrow chromosome study revealed 50,XY,trp(1)(q21q32),+3,+add(3)(q21),+7,+9,add(13)(p11.2)[11]/51 approximately 52,idem,+19,+22[8]/46,XY[3]. Review of the Mitelman Database of Chromosome Aberrations in Cancer revealed 7 previous cases of non-Burkitt type lymphoma (including FL) with 1q triplication. On the basis of these eight cases, we conclude that 1q triplication represents a rare secondary genetic event with prognostic significance in patients with FL or other non-Burkitt types of lymphoma. Further studies are needed to investigate these rare 1q triplication in hematologic malignancies.