Gene structures and processing of Arabidopsis thaliana HYL1-dependent pri-miRNAs.

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Tytuł:: Gene structures and processing of Arabidopsis thaliana HYL1-dependent pri-miRNAs.
Autorzy:: Szarzynska B; Department of Gene Expression, Faculty of Biology, Institute of Molecular Biology and Biotechnology, Adam Mickiewicz University, Poznan, Poland.
Sobkowiak L
Pant BD
Balazadeh S
Scheible WR
Mueller-Roeber B
Jarmolowski A
Szweykowska-Kulinska Z
Źródło:: Nucleic acids research [Nucleic Acids Res] 2009 May; Vol. 37 (9), pp. 3083-93. Date of Electronic Publication: 2009 Mar 20.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Publication: 1992- : Oxford : Oxford University Press
Original Publication: London, Information Retrieval ltd.
MeSH Terms:: Alternative Splicing*
Gene Expression Regulation, Plant*
Arabidopsis/*genetics
Arabidopsis Proteins/*metabolism
MicroRNAs/*genetics
RNA-Binding Proteins/*metabolism
Arabidopsis/metabolism ; Arabidopsis Proteins/genetics ; Genes, Plant ; Introns ; MicroRNAs/chemistry ; MicroRNAs/metabolism ; Mutation ; RNA Precursors/chemistry ; RNA Precursors/metabolism ; RNA Processing, Post-Transcriptional ; RNA-Binding Proteins/genetics
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Substance Nomenclature:: 0 (Arabidopsis Proteins)
0 (HYL1 protein, Arabidopsis)
0 (MicroRNAs)
0 (RNA Precursors)
0 (RNA-Binding Proteins)
Entry Date(s):: Date Created: 20090324 Date Completed: 20090714 Latest Revision: 20211020
Update Code:: 20240104
PubMed Central ID:: PMC2685107
DOI:: 10.1093/nar/gkp189
PMID:: 19304749
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Arabidopsis thaliana HYL1 is a nuclear double-stranded RNA-binding protein involved in the maturation of pri-miRNAs. A quantitative real-time PCR platform for parallel quantification of 176 pri-miRNAs was used to reveal strong accumulation of 57 miRNA precursors in the hyl1 mutant that completely lacks HYL1 protein. This approach enabled us for the first time to pinpoint particular members of MIRNA family genes that require HYL1 activity for efficient maturation of their precursors. Moreover, the accumulation of miRNA precursors in the hyl1 mutant gave us the opportunity to carry out 3' and 5' RACE experiments which revealed that some of these precursors are of unexpected length. The alignment of HYL1-dependent miRNA precursors to A. thaliana genomic sequences indicated the presence of introns in 12 out of 20 genes studied. Some of the characterized intron-containing pri-miRNAs undergo alternative splicing such as exon skipping or usage of alternative 5' splice sites suggesting that this process plays a role in the regulation of miRNA biogenesis. In the hyl1 mutant intron-containing pri-miRNAs accumulate alongside spliced pri-miRNAs suggesting the recruitment of HYL1 into the miRNA precursor maturation pathway before their splicing occurs.

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