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Tytuł pozycji:

Hepatoma cell uptake of cationic multifluorescent quantum dot liposomes.

Tytuł:
Hepatoma cell uptake of cationic multifluorescent quantum dot liposomes.
Autorzy:
Bothun GD; Department of Chemical Engineering, University of Rhode Island, 205 Crawford Hall, Kingston, Rhode Island 02881, USA. />Rabideau AE
Stoner MA
Źródło:
The journal of physical chemistry. B [J Phys Chem B] 2009 Jun 04; Vol. 113 (22), pp. 7725-8.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
Język:
English
Imprint Name(s):
Original Publication: Washington, D.C. : American Chemical Society, c1997-
MeSH Terms:
Quantum Dots*
Cadmium Compounds/*analysis
Liposomes/*metabolism
Selenium Compounds/*analysis
Sulfides/*analysis
Zinc Compounds/*analysis
Cadmium Compounds/administration & dosage ; Carcinoma, Hepatocellular/diagnosis ; Cations/chemistry ; Cell Line, Tumor ; Cell Membrane Permeability ; Humans ; Liposomes/analysis ; Microscopy, Fluorescence ; Selenium Compounds/administration & dosage ; Sulfides/administration & dosage ; Transition Temperature ; Zinc Compounds/administration & dosage
Grant Information:
P20RR016457 United States RR NCRR NIH HHS
Substance Nomenclature:
0 (Cadmium Compounds)
0 (Cations)
0 (Liposomes)
0 (Selenium Compounds)
0 (Sulfides)
0 (Zinc Compounds)
A7F646JC5C (cadmium selenide)
KPS085631O (zinc sulfide)
Entry Date(s):
Date Created: 20090529 Date Completed: 20090810 Latest Revision: 20121115
Update Code:
20240104
DOI:
10.1021/jp9017458
PMID:
19473036
Czasopismo naukowe
Cationic multifluorescent quantum dot liposomes (QD-Ls) have been prepared with both hydrophobic and hydrophilic CdSe/ZnS quantum dots by reverse phase evaporation. QD incorporation was confirmed by fluorescence and confocal microscopy. Incorporation did not affect QD photoactivity or damage bilayer or liposome structure. Cell uptake was examined in human hepatocellular carcinoma cells (HuH-7) using cationic and zwitterionic QD-Ls. Cationic QD-Ls were stable in vitro and exhibited high uptake, while zwitterionic QD-Ls aggregated and exhibited low uptake. Given that liposomes are established and versatile platforms for creating cell-targeting therapeutic agents, multifluorescent QD-Ls may offer advanced techniques for imaging hydrophobic and hydrophilic domains simultaneously. If coupled with an encapsulated drug, QD-Ls could be multifunctional and provide imaging, detection, and drug delivery in a single assembly.

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