Blood levels of homocysteine, cysteine, glutathione, folic acid, and vitamin B12 in the acute phase of atherothrombotic stroke.

Szczegóły
Abstrakt

Tytuł:: Blood levels of homocysteine, cysteine, glutathione, folic acid, and vitamin B12 in the acute phase of atherothrombotic stroke.
Autorzy:: Salemi G; Section of Neurology, Department of Clinical Neuroscience, University of Palermo, Via Gaetano La Loggia 1, 90129, Palermo, Italy. />Gueli MC
D'Amelio M
Saia V
Mangiapane P
Aridon P
Ragonese P
Lupo I
Źródło:: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology [Neurol Sci] 2009 Aug; Vol. 30 (4), pp. 361-4. Date of Electronic Publication: 2009 May 30.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Original Publication: Milano, Italy : Springer-Verlag Italia, c2000-
MeSH Terms:: Cysteine/*blood
Glutathione/*blood
Homocysteine/*blood
Intracranial Thrombosis/*blood
Stroke/*blood
Vitamins/*blood
Acute Disease ; Aged ; Aged, 80 and over ; Brain Ischemia/blood ; Brain Ischemia/complications ; Female ; Folic Acid/blood ; Humans ; Hyperhomocysteinemia/blood ; Intracranial Thrombosis/complications ; Male ; Middle Aged ; Risk Factors ; Stroke/etiology ; Vitamin B 12/blood
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Substance Nomenclature:: 0 (Vitamins)
0LVT1QZ0BA (Homocysteine)
935E97BOY8 (Folic Acid)
GAN16C9B8O (Glutathione)
K848JZ4886 (Cysteine)
P6YC3EG204 (Vitamin B 12)
Entry Date(s):: Date Created: 20090602 Date Completed: 20121227 Latest Revision: 20211020
Update Code:: 20240104
DOI:: 10.1007/s10072-009-0090-2
PMID:: 19484186
: Czasopismo naukowe

Pełny tekst

Blood levels of total homocysteine (tHcy), cysteine (Cys), total and reduced glutathione (tGSH and rGSH), folic acid (FA), and vitamin B12 (B12) change during ischemic stroke as accompaniment of the tissue damage. The relationship between these changes remains scantly investigated. We evaluated the variation of these molecules in the 48 h after acute large artery atherothrombotic stroke (LAAS) and searched for the presence of matched variation of them. The study involved 50 subjects affected by acute LAAS and 49 healthy controls. Plasma levels of tHcy and Cys were significantly higher and serum levels of FA and B12 and plasma levels of rGSH were significantly lower in the patients than in the control group. Acute LAAS was associated with increased Hcy-decreased tGSH and decreased FA/tGSH. Pathways involved in cellular stress and in tissue repair are activated during acute LAAS.

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