Biracial population study of mortality in mild cognitive impairment and Alzheimer disease.

Szczegóły
Abstrakt

Tytuł:: Biracial population study of mortality in mild cognitive impairment and Alzheimer disease.
Autorzy:: Wilson RS; Rush Alzheimer's Disease Center, Rush University Medical Center, 600 S Paulina Ave, Ste 1038, Chicago, IL 60612, USA. />Aggarwal NT
Barnes LL
Bienias JL
Mendes de Leon CF
Evans DA
Źródło:: Archives of neurology [Arch Neurol] 2009 Jun; Vol. 66 (6), pp. 767-72.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
Język:: English
Imprint Name(s):: Original Publication: Chicago, American Medical Assn.
MeSH Terms:: Alzheimer Disease/*mortality
Brain/*metabolism
Cognition Disorders/*mortality
Black or African American ; Age Distribution ; Aged ; Aged, 80 and over ; Alzheimer Disease/ethnology ; Alzheimer Disease/genetics ; Brain/physiopathology ; Cognition Disorders/ethnology ; Cognition Disorders/genetics ; Cohort Studies ; Disease Progression ; Female ; Humans ; Incidence ; Life Expectancy/trends ; Longitudinal Studies ; Male ; Mortality/trends ; Racial Groups ; Survival Rate/trends ; White People
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Grant Information:: R01 ES010902-09 United States ES NIEHS NIH HHS; P30 AG010161 United States AG NIA NIH HHS; AG10161 United States AG NIA NIH HHS; R01 AG011101 United States AG NIA NIH HHS; AG 11101 United States AG NIA NIH HHS; R01 ES010902 United States ES NIEHS NIH HHS; R01 AG011101-15 United States AG NIA NIH HHS; ES 10902 United States ES NIEHS NIH HHS; P30 AG010161-18 United States AG NIA NIH HHS
Entry Date(s):: Date Created: 20090610 Date Completed: 20090803 Latest Revision: 20221207
Update Code:: 20240104
PubMed Central ID:: PMC2743243
DOI:: 10.1001/archneurol.2009.80
PMID:: 19506138
: Czasopismo naukowe

Objective: To assess mortality associated with mild cognitive impairment (MCI) and Alzheimer disease (AD) among older African Americans and whites from an urban community.
Design: Longitudinal population-based observational study.
Setting: Four adjacent neighborhoods in Chicago, Illinois.
Participants: Persons deemed free of dementia in a previous wave of data collection (n = 1715) underwent detailed clinical evaluation: 802 had no cognitive impairment (46.8%), 597 had MCI (34.8%), 296 had AD (17.3%), and 20 had other forms of dementia (1.2%).
Main Outcome Measure: All-cause mortality.
Results: During as many as 10 years of observation (mean [SD], 4.7 [3.0] years), 634 individuals died (37.0%). Compared with people without cognitive impairment, risk of death was increased by about 50% among those with MCI (hazard ratio [95% confidence interval], 1.48 [1.22-1.80]) and was nearly 3-fold greater among those with AD (2.84 [2.29-3.52]). These effects were seen among African Americans and whites and did not differ by race. Among participants with MCI, risk of death increased with more severe cognitive impairment, and this effect did not vary by race. A similar effect was seen among participants with AD, but it was slightly stronger for African Americans vs whites. In the MCI and AD groups, the association of cognitive impairment with survival was stronger for perceptual speed than for other cognitive functions.
Conclusion: The presence and severity of MCI and AD are associated with reduced survival among African Americans, and these effects are comparable to those seen among whites.

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