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Tytuł:
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Differential sensing using proteins: exploiting the cross-reactivity of serum albumin to pattern individual terpenes and terpenes in perfume.
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Autorzy:
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Adams MM; Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, Texas 78712, USA.
Anslyn EV
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Źródło:
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Journal of the American Chemical Society [J Am Chem Soc] 2009 Dec 02; Vol. 131 (47), pp. 17068-9.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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Język:
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English
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Imprint Name(s):
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Publication: Washington, DC : American Chemical Society
Original Publication: Easton, Pa. [etc.]
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MeSH Terms:
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Perfume/*chemistry
Serum Albumin/*chemistry
Terpenes/*chemistry
Cross Reactions
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Substance Nomenclature:
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0 (Perfume)
0 (Serum Albumin)
0 (Terpenes)
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Entry Date(s):
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Date Created: 20091113 Date Completed: 20100121 Latest Revision: 20091125
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Update Code:
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20240104
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DOI:
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10.1021/ja908319m
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PMID:
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19904949
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There has been a growing interest in the use of differential sensing for analyte classification. In an effort to mimic the mammalian senses of taste and smell, which utilize protein-based receptors, we have introduced serum albumins as nonselective receptors for recognition of small hydrophobic molecules. Herein, we employ a sensing ensemble consisting of serum albumins, a hydrophobic fluorescent indicator (PRODAN), and a hydrophobic additive (deoxycholate) to detect terpenes. With the aid of linear discriminant analysis, we successfully applied our system to differentiate five terpenes. We then extended our terpene analysis and utilized our sensing ensemble for terpene discrimination within the complex mixtures found in perfume.