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Tytuł pozycji:

An assessment of the effect of human herpesvirus-6 replication on active cytomegalovirus infection after allogeneic stem cell transplantation.

Tytuł:
An assessment of the effect of human herpesvirus-6 replication on active cytomegalovirus infection after allogeneic stem cell transplantation.
Autorzy:
Tormo N; Microbiology Service, Hospital Clínico Universitario, Valencia, Spain.
Solano C
de la Cámara R
Garcia-Noblejas A
Cardeñoso L
Clari MA
Nieto J
López J
Hernández-Boluda JC
Remigia MJ
Benet I
Navarro D
Źródło:
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation [Biol Blood Marrow Transplant] 2010 May; Vol. 16 (5), pp. 653-61. Date of Electronic Publication: 2010 Jan 29.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
Język:
English
Imprint Name(s):
Publication: Charlottesville, VA : Carden Jennings Publishing
Original Publication: Charlottesville, VA : Kluge Carden Jennings Publishing, Co., Ltd., [1995-
MeSH Terms:
Virus Replication*
Cytomegalovirus Infections/*etiology
Hematopoietic Stem Cell Transplantation/*adverse effects
Herpesvirus 6, Human/*physiology
Adolescent ; Adult ; Aged ; Cytomegalovirus Infections/virology ; DNA, Viral/blood ; Female ; Humans ; Immunosuppression Therapy/adverse effects ; Male ; Middle Aged ; Roseolovirus Infections/complications ; Transplantation, Homologous ; Virus Activation ; Young Adult
Substance Nomenclature:
0 (DNA, Viral)
Entry Date(s):
Date Created: 20091217 Date Completed: 20100813 Latest Revision: 20211203
Update Code:
20240104
DOI:
10.1016/j.bbmt.2009.12.003
PMID:
20005968
Czasopismo naukowe
Human herpesvirus-6 (HHV-6) may enhance cytomegalovirus (CMV) replication in allogeneic stem cell transplant (allo-SCT) recipients either through direct or indirect mechanisms. Definitive evidence supporting this hypothesis are lacking. We investigated the effect of HHV-6 replication on active CMV infection in 68 allo-SCT recipients. Analysis of plasma HHV-6 and CMV DNAemia was performed by real-time PCR. Enumeration of pp65 and IE-1 CMV-specific IFNgamma CD8(+) and CD4(+)T cells was performed by intracellular cytokine staining. HHV-6 DNAemia occurred in 39.8% of patients, and was significantly associated with subsequent CMV DNAemia in univariate (P=.01), but not in multivariate analysis (P=.65). The peak of HHV-6 DNAemia was not predictive of the development of CMV DNAemia. Timing and kinetics of active CMV infection were comparable in patients either with or without a preceding episode of HHV-6 DNAemia. The occurrence of HHV-6 DNAemia had no impact on CMV-specific T cell immunity reconstitution early after transplant. The receipt of a graft from an HLA-mismatched donor was independently associated with HHV-6 (P=.009) and CMV reactivation (P=.04). The data favor the hypothesis that a state of severe immunosuppression leads to HHV-6 and CMV coactivation, but argue against a role of HHV-6 in predisposing to the development of CMV DNAemia or influencing the course of active CMV infection.
(Copyright 2010 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.)

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