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Tytuł pozycji:

Expression of apoptosis in human saphenous vein grafts in restoration of blood flow through coronary bypass surgery.

Tytuł:
Expression of apoptosis in human saphenous vein grafts in restoration of blood flow through coronary bypass surgery.
Autorzy:
Tirapelli LF; FMRP - USP. />Tirapelli DP
Dalio MB
Rodrigues AJ
Evora PR
Źródło:
Revista brasileira de cirurgia cardiovascular : orgao oficial da Sociedade Brasileira de Cirurgia Cardiovascular [Rev Bras Cir Cardiovasc] 2009 Jul-Sep; Vol. 24 (3), pp. 312-7.
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Original Publication: São Paulo, SP, Brasil : Sociedade Brasileira de Cirurgia Cardiovascular
MeSH Terms:
Coronary Artery Bypass*
Stress, Mechanical*
Apoptosis/*physiology
Saphenous Vein/*metabolism
Caspase 3/metabolism ; Caspase 8/metabolism ; Caspase 9/metabolism ; Humans ; Pressure ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Regional Blood Flow/physiology ; Saphenous Vein/pathology
Substance Nomenclature:
0 (Proto-Oncogene Proteins c-bcl-2)
EC 3.4.22.- (CASP3 protein, human)
EC 3.4.22.- (CASP8 protein, human)
EC 3.4.22.- (CASP9 protein, human)
EC 3.4.22.- (Caspase 3)
EC 3.4.22.- (Caspase 8)
EC 3.4.22.- (Caspase 9)
Entry Date(s):
Date Created: 20091217 Date Completed: 20100602 Latest Revision: 20190608
Update Code:
20240104
DOI:
10.1590/s0102-76382009000400009
PMID:
20011876
Czasopismo naukowe
Objective: To investigate the possible role of apoptosis on brief distensions of human saphenous veins at different pressures.
Methods: Fresh isolated grafts of human saphenous vein were assigned as control or distended (D) for fifteen seconds at 100, 200 and 300 mmHg. The degree of apoptotic caspases 3, 8, 9 and anti-apoptotic protein Bcl-2 expression were assessed by immunohistochemistry.
Results: Fresh isolated segments of distended human saphenous veins presented similar apoptotic protein expression when compared with control veins. However, the Bcl-2 expression was significantly higher in the 300 mmHg distended segments compared with the control vein.
Conclusion: These findings show that intact segments of human saphenous veins submitted to distensions at different pressures have similar apoptotic proteins expression when compared with non-distended control veins. Therefore, brief distensions commonly performed during surgical harvesting do not trigger apoptosis, and probably are not involved on the physiopathological mechanisms that lead to graft failure.

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