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Tytuł:
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New paradigms for treating hepatitis B in HIV/hepatitis B virus co-infected patients.
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Autorzy:
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Martin-Carbonero L; Department of Infectious Diseases, Hospital Carlos III, Madrid, Spain. />Soriano V
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Źródło:
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The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 2010 Mar; Vol. 65 (3), pp. 379-82. Date of Electronic Publication: 2010 Jan 19.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Publication: 1997- : London : Oxford University Press
Original Publication: London, New York, Academic Press.
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MeSH Terms:
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Antiviral Agents/*therapeutic use
HIV Infections/*complications
HIV Infections/*drug therapy
Hepatitis B, Chronic/*complications
Hepatitis B, Chronic/*drug therapy
Drug Monitoring ; Drug Resistance, Viral ; Humans ; Viral Load
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Substance Nomenclature:
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0 (Antiviral Agents)
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Entry Date(s):
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Date Created: 20100121 Date Completed: 20100421 Latest Revision: 20100210
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Update Code:
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20240104
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DOI:
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10.1093/jac/dkp492
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PMID:
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20085999
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Until the advent of tenofovir, many HIV/hepatitis B virus (HBV) co-infected patients had been treated with lamivudine as the only agent active against HBV. Selection of lamivudine-resistant HBV strains occurred in many of these patients, complicating clinical prognosis and rescue therapy. These individuals might also transmit HBV-resistant strains. Moreover, a subset of these lamivudine-resistant HBV isolates may behave as vaccine escape mutants, complicating diagnostic accuracy (e.g. producing 'occult' hepatitis B) and reducing the efficacy of preventive measures (causing infection in vaccinated persons). Nowadays, periodic monitoring of HBV viral load in co-infected patients should be mandatory. It may allow the early recognition of HBV viraemic individuals who may benefit from either initiating or switching antiviral therapy. In any situation, the use of anti-HBV therapies more potent than lamivudine alone is warranted.