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Tytuł:
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Effect of day-to-day variations in adrenal cortex hormone levels on abdominal symptoms.
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Autorzy:
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Sugaya N; Faculty of Human Sciences, Waseda University, 2-579-15 Mikajima, Tokorozawa, Saitama 359-1192, Japan. />Izawa S
Ogawa N
Shirotsuki K
Kobayashi H
Yamada KC
Tsumura H
Nomura S
Shimada H
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Źródło:
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BioPsychoSocial medicine [Biopsychosoc Med] 2010 Mar 18; Vol. 4 (1), pp. 2. Date of Electronic Publication: 2010 Mar 18.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: London : BioMed Central, c2007-
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References:
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Entry Date(s):
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Date Created: 20100320 Date Completed: 20100617 Latest Revision: 20200930
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Update Code:
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20240104
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PubMed Central ID:
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PMC2848621
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DOI:
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10.1186/1751-0759-4-2
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PMID:
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20298587
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Introduction: The hypothalamic-pituitary-adrenal axis is known to be related to abdominal symptoms, and the relationship between abdominal pain and cortisol secretory patterns has been previously investigated using a cross-sectional approach. Here, we investigated the effect of day-to-day variations in salivary cortisol and dehydroepiandrosterone-sulfate levels on abdominal symptoms in healthy individuals.
Methods: Eleven college students (4 males and 7 females) participated in this study. The participants were asked to collect their saliva immediately after awakening and before bedtime for eight consecutive days. They also completed a questionnaire about abdominal symptoms before bedtime. The linear mixed model was applied to analyze the effects of the day-by-day variability or the 8-day average adrenal hormone level (at awakening, before bedtime, slope from awakening to bedtime) on abdominal symptoms.
Results: The day-to-day variability of cortisol levels before bedtime was negatively related with loose stool, while the day-to-day variability of the cortisol slope was positively correlated with loose stool. A low 8-day average dehydroepiandrosterone-sulfate level at awakening was positively related with frequent bowel movements, loose stool, and long bouts of severe abdominal pain. Likewise, a low 8-day average dehydroepiandrosterone-sulfate slope was positively related with long bouts of abdominal pain.
Conclusions: Low cortisol levels before bedtime and a steeper diurnal cortisol slope during the day may be related to bouts of diarrhea during the day.
