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Tytuł pozycji:

Global distribution and evolution of Panton-Valentine leukocidin-positive methicillin-susceptible Staphylococcus aureus, 1981-2007.

Tytuł:
Global distribution and evolution of Panton-Valentine leukocidin-positive methicillin-susceptible Staphylococcus aureus, 1981-2007.
Autorzy:
Rasigade JP; Université Lyon 1, Centre National de Référence des Staphylocoques, and Institut National de la Santé et de la Recherche Médicale U851, Institut Fédératif de Recherche 128, Lyon, France. />Laurent F
Lina G
Meugnier H
Bes M
Vandenesch F
Etienne J
Tristan A
Źródło:
The Journal of infectious diseases [J Infect Dis] 2010 May 15; Vol. 201 (10), pp. 1589-97.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
Język:
English
Imprint Name(s):
Publication: Jan. 2011- : Oxford : Oxford University Press
Original Publication: 1904-2010 : Chicago, IL : University of Chicago Press
MeSH Terms:
Biological Evolution*
Bacterial Toxins/*genetics
Exotoxins/*genetics
Leukocidins/*genetics
Methicillin/*pharmacology
Staphylococcus aureus/*genetics
Staphylococcus aureus/*metabolism
Anti-Bacterial Agents/pharmacology ; Drug Resistance, Multiple, Bacterial ; Genetic Variation ; Staphylococcus aureus/drug effects ; Time Factors
Substance Nomenclature:
0 (Anti-Bacterial Agents)
0 (Bacterial Toxins)
0 (Exotoxins)
0 (Leukocidins)
0 (Panton-Valentine leukocidin)
Q91FH1328A (Methicillin)
Entry Date(s):
Date Created: 20100407 Date Completed: 20100505 Latest Revision: 20220408
Update Code:
20240104
DOI:
10.1086/652008
PMID:
20367458
Czasopismo naukowe
Background: Panton-Valentine leukocidin (PVL)-positive methicillin-susceptible Staphylococcus aureus and methicillin-resistant S. aureus (MSSA and MRSA, respectively) are both associated with severe infections, such as necrotizing pneumonia. The epidemiological profile of PVL-positive community-acquired (CA) MRSA has been extensively studied, but few corresponding data on PVL-positive MSSA are available.
Objectives: The objectives of the study were to investigate the global population structure of PVL-positive MSSA, to compare it with that reported for CA-MRSA, and thus to examine the phylogenetic relationship between these pathogens.
Methods: We determined the agr types, multilocus sequence types, and toxin gene profiles of 211 PVL-positive MSSA clinical isolates collected in 19 countries throughout the world between 1981 and 2007.
Results: The predominant lineages of PVL-positive MSSA were agr3/ST30, agr4/ST121, agr3/ST1, agr2/ST5, and agr3/ST80. Except for agr4/ST121, these lineages are also reported to be prevalent among CA-MRSA. PVL-positive MSSA lineages that are genetically related to CA-MRSA have gradually replaced other lineages (especially agr4/ST121) over the past 2 decades. Within a given sequence type, the toxin gene content of PVL-positive MSSA strains was very similar to that of PVL-positive CA-MRSA.
Conclusions: The molecular epidemiological profiles of PVL-positive MSSA and CA-MRSA are dynamically interrelated, with the former appearing to constitute a reservoir for the latter.

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