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Tytuł pozycji:

Development and optimization of micro/nanoporous osmotic pump tablets.

Tytuł:
Development and optimization of micro/nanoporous osmotic pump tablets.
Autorzy:
Tuntikulwattana S; Department of Industrial Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok, 10400, Thailand.
Mitrevej A
Kerdcharoen T
Williams DB
Sinchaipanid N
Źródło:
AAPS PharmSciTech [AAPS PharmSciTech] 2010 Jun; Vol. 11 (2), pp. 924-35. Date of Electronic Publication: 2010 May 25.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
Język:
English
Imprint Name(s):
Publication: New York : Springer
Original Publication: Arlington, VA : American Association of Pharmaceutical Scientists, c2000-
MeSH Terms:
Membranes, Artificial*
Microspheres*
Tablets*
Nanocapsules/*chemistry
Povidone/*chemistry
Drug Compounding/methods ; Osmotic Pressure ; Porosity ; Surface Properties
References:
Curr Opin Cardiol. 2007 Jul;22(4):298-305. (PMID: 17556881)
J Pharm Sci. 2002 Sep;91(9):2040-6. (PMID: 12210050)
J Control Release. 1999 Aug 5;60(2-3):311-9. (PMID: 10425336)
Acta Pharm. 2003 Dec;53(4):263-73. (PMID: 14769233)
Eur J Pharm Biopharm. 2008 May;69(1):303-11. (PMID: 18053697)
J Control Release. 2003 Apr 14;89(1):47-55. (PMID: 12695062)
Hypertension. 2003 Dec;42(6):1093-9. (PMID: 14610100)
Int J Pharm. 2004 Nov 22;286(1-2):81-8. (PMID: 15501004)
Drug Dev Ind Pharm. 2002 Apr;28(4):403-12. (PMID: 12056533)
Pharm Res. 1991 Jan;8(1):88-92. (PMID: 2014214)
Drug Dev Ind Pharm. 2000 Jul;26(7):745-54. (PMID: 10872093)
Pharm Res. 1991 May;8(5):600-4. (PMID: 1866374)
J Pharm Sci. 1975 Dec;64(12):1987-91. (PMID: 1510)
Eur J Pharm Biopharm. 2004 May;57(3):513-25. (PMID: 15093601)
Int J Pharm. 2003 Sep 16;263(1-2):9-24. (PMID: 12954176)
J Control Release. 2002 Feb 19;79(1-3):7-27. (PMID: 11853915)
Substance Nomenclature:
0 (Membranes, Artificial)
0 (Nanocapsules)
0 (Tablets)
FZ989GH94E (Povidone)
Entry Date(s):
Date Created: 20100526 Date Completed: 20101008 Latest Revision: 20211020
Update Code:
20231215
PubMed Central ID:
PMC2902301
DOI:
10.1208/s12249-010-9446-4
PMID:
20499218
Czasopismo naukowe
Micro/nanoporous osmotic pump tablets coated with cellulose acetate containing polyvinylpyrolidone (PVP) as pore formers were fabricated. Propranolol hydrochloride was used as a model drug in this study. Formulation optimization based on USP 31 requirements was conducted following a central composite design using a two-level factorial plan involving two membrane variables (pore former and coating levels). Effect of molecular weight of pore former (PVP K30 and PVP K90) was also evaluated. Responses of drug release to the variables were analyzed using statistical software (MINITAB 14). Scanning electron microscopy and atomic force microscopy showed that the pores formed by PVP. The drug release was dependent on the molecular weight and concentration of PVP and the level of coating. The results showed that acceptable 12-h profile could be achieved with only specific range of PVP K30-containing membrane at the defined membrane thickness. However, satisfactory 24-h profile could be accomplished by both PVP K30 and PVP K90-containing membrane at the range and membrane thickness tested. Preparation and testing of the optimized formulation showed a good correlation between predicted and observed values.

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