Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture.

Tytuł:: Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture.
Autorzy:: Goldman N; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, New York, USA.
Chen M
Fujita T
Xu Q
Peng W
Liu W
Jensen TK
Pei Y
Wang F
Han X
Chen JF
Schnermann J
Takano T
Bekar L
Tieu K
Nedergaard M
Źródło:: Nature neuroscience [Nat Neurosci] 2010 Jul; Vol. 13 (7), pp. 883-8. Date of Electronic Publication: 2010 May 30.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
Język:: English
Imprint Name(s):: Publication: <2002->: New York, NY : Nature Publishing Group
Original Publication: New York, NY : Nature America Inc., c1998-
MeSH Terms:: Acupuncture Analgesia*
Adenosine/*metabolism
Afferent Pathways/*metabolism
Pain/*metabolism
Peripheral Nervous System Diseases/*metabolism
Receptors, Purinergic P1/*metabolism
Analysis of Variance ; Animals ; Disease Models, Animal ; Mice ; Nucleotidases/metabolism ; Pain/complications ; Pain Management ; Peripheral Nervous System Diseases/complications ; Peripheral Nervous System Diseases/therapy ; Sciatica/complications ; Sciatica/metabolism ; Sciatica/therapy ; Statistics, Nonparametric
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Grant Information:: R21 ES017470 United States ES NIEHS NIH HHS; Z99 DA999999 United States ImNIH Intramural NIH HHS; R01 NS075177 United States NS NINDS NIH HHS; R01 ES014899 United States ES NIEHS NIH HHS; R01 ES014899-04 United States ES NIEHS NIH HHS; Z99 OD999999 United States ImNIH Intramural NIH HHS; R21 ES017470-01 United States ES NIEHS NIH HHS; Z99 DK999999 United States ImNIH Intramural NIH HHS
Substance Nomenclature:: 0 (Receptors, Purinergic P1)
EC 3.1.3.- (Nucleotidases)
EC 3.1.3.- (adenosine monophosphatase)
K72T3FS567 (Adenosine)
Entry Date(s):: Date Created: 20100601 Date Completed: 20100730 Latest Revision: 20230610
Update Code:: 20240104
PubMed Central ID:: PMC3467968
DOI:: 10.1038/nn.2562
PMID:: 20512135
: Czasopismo naukowe

Pełny tekst

Acupuncture is an invasive procedure commonly used to relieve pain. Acupuncture is practiced worldwide, despite difficulties in reconciling its principles with evidence-based medicine. We found that adenosine, a neuromodulator with anti-nociceptive properties, was released during acupuncture in mice and that its anti-nociceptive actions required adenosine A1 receptor expression. Direct injection of an adenosine A1 receptor agonist replicated the analgesic effect of acupuncture. Inhibition of enzymes involved in adenosine degradation potentiated the acupuncture-elicited increase in adenosine, as well as its anti-nociceptive effect. These observations indicate that adenosine mediates the effects of acupuncture and that interfering with adenosine metabolism may prolong the clinical benefit of acupuncture.

Comment in: Nat Neurosci. 2010 Jul;13(7):783-4. (PMID: 20581811)

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