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Tytuł pozycji:

In vitro release, rheological, and stability studies of mefenamic acid coprecipitates in topical formulations.

Tytuł :
In vitro release, rheological, and stability studies of mefenamic acid coprecipitates in topical formulations.
Autorzy :
Ahmed TA; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.
Ibrahim HM
Ibrahim F
Samy AM
Fetoh E
Nutan MT
Pokaż więcej
Źródło :
Pharmaceutical development and technology [Pharm Dev Technol] 2011 Oct; Vol. 16 (5), pp. 497-510. Date of Electronic Publication: 2010 Jun 16.
Typ publikacji :
Journal Article
Język :
English
Imprint Name(s) :
Publication: London : Informa Healthcare
Original Publication: Monticello, NY : Marcel Dekker, c1996-
MeSH Terms :
Mefenamic Acid*/chemistry
Mefenamic Acid*/pharmacokinetics
Anti-Inflammatory Agents, Non-Steroidal/*chemistry
Drug Delivery Systems/*methods
Absorption ; Acrylic Resins ; Administration, Topical ; Biological Availability ; Drug Compounding ; Drug Stability ; Gels/chemistry ; Humans ; Methylcellulose/analogs & derivatives ; Methylcellulose/chemistry ; Ointment Bases/administration & dosage ; Ointments/administration & dosage ; Polyethylenes/chemistry ; Polypropylenes/chemistry ; Polyvinyls/chemistry ; Pyrrolidines/chemistry ; Rheology ; Viscosity
Substance Nomenclature :
0 (Acrylic Resins)
0 (Anti-Inflammatory Agents, Non-Steroidal)
0 (Gels)
0 (Ointment Bases)
0 (Ointments)
0 (Polyethylenes)
0 (Polypropylenes)
0 (Polyvinyls)
0 (Pyrrolidines)
0 (poly(N-vinylpyrrolidine))
0A5MM307FC (carboxypolymethylene)
367589PJ2C (Mefenamic Acid)
9004-67-5 (Methylcellulose)
9038-95-3 (UCON 50-HB-5100)
Entry Date(s) :
Date Created: 20100617 Date Completed: 20120222 Latest Revision: 20161125
Update Code :
20210209
DOI :
10.3109/10837450.2010.495394
PMID :
20550465
Czasopismo naukowe
A suitable topical formulation of mefenamic acid was developed in order to eliminate the gastrointestinal disorders associated with its oral administration. Drug coprecipitates prepared with different polymers at various drug-to-polymer ratios improved drug solubility and dissolution compared to pure drug and physical mixtures. PVP polymers (ratio 1:4) produced the best results. Aqueous ionic cream, ointments of absorption and water soluble bases and gels of methylcellulose, carboxymethylcellulose sodium, HPMC, Carbopol® 934 and 940, and Pluronic® F127 bases containing 1-10% drug as coprecipitates of PVP polymers (1:4) were prepared. The highest drug release was achieved at 1% drug concentration from water soluble base and methylcellulose among cream/ointment and gel bases, respectively. Gels, in general yielded better release than creams/ointments. All tested medicated creams/ointments exhibited plastic flow while all gels conformed to pseudoplasticity. Most of them showed thixotropy, a desired property of topical preparations. Stability studies revealed that HPMC and methylcellulose had the smallest changes in drug content, viscosity, and pH among the formulations. Considering drug release, rheological properties, and stability, methylcellulose gel containing 1% drug as coprecipitates of PVP K90 was the best among the studied formulations, was promising for improving bioavailability of mefenamic acid and can be used in future studies.
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