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Tytuł pozycji:

Characteristics of granuloma formation and liver fibrosis in murine schistosomiasis mekongi: a morphological comparison between Schistosoma mekongi and S. japonicum infection.

Tytuł :
Characteristics of granuloma formation and liver fibrosis in murine schistosomiasis mekongi: a morphological comparison between Schistosoma mekongi and S. japonicum infection.
Autorzy :
Shimada M; Laboratory of Tropical Medicine and Parasitology, Dokkyo Medical University, Mibu, Shimotsuga, Tochigi 321-0293, Japan.
Kirinoki M
Shimizu K
Kato-Hayashi N
Chigusa Y
Kitikoon V
Pongsasakulchoti P
Matsuda H
Pokaż więcej
Źródło :
Parasitology [Parasitology] 2010 Oct; Vol. 137 (12), pp. 1781-9. Date of Electronic Publication: 2010 Jun 21.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
Język :
English
Imprint Name(s) :
Original Publication: London, New York, Cambridge University Press.
MeSH Terms :
Granuloma/*pathology
Liver Cirrhosis/*pathology
Schistosoma/*pathogenicity
Schistosoma japonicum/*pathogenicity
Schistosomiasis/*parasitology
Schistosomiasis japonica/*parasitology
Animals ; Female ; Foam Cells/cytology ; Granuloma/parasitology ; Host-Parasite Interactions ; Intestine, Small/parasitology ; Intestine, Small/pathology ; Liver/parasitology ; Liver/pathology ; Liver Cirrhosis/parasitology ; Lung/parasitology ; Lung/pathology ; Mice ; Mice, Inbred ICR ; Ovum ; Schistosoma/classification ; Schistosoma/growth & development ; Schistosoma japonicum/growth & development ; Species Specificity
Entry Date(s) :
Date Created: 20100622 Date Completed: 20110128 Latest Revision: 20101006
Update Code :
20211220
DOI :
10.1017/S0031182010000806
PMID :
20561395
Czasopismo naukowe
A histopathological study was performed to clarify the characteristics of granuloma formation and liver fibrosis in Schistosoma mekongi infection in comparison with S. japonicum infection. Mice were exposed to S. mekongi (Laotian strain) and S. japonicum (Japanese strain) cercariae, and were dissected at 6, 8, 12, 16, and 20 weeks post-exposure. In the liver, granulomas in S. mekongi infection were cellular, initially organized with foam cells, and continuously appeared in the intralobular area, while granulomas in S. japonicum infection were fibrous and did not continuously appear in the intralobular area. Portal fibrosis was not seen in S. mekongi infection, but was commonly seen in S. japonicum infection in the later weeks. Granulomas in the small intestine were seen mainly in the submucosa with foam cells in S. mekongi infection and without foam cells in S. japonicum infection. The lung granulomas contained mainly histiocytes in both S. mekongi and S. japonicum infection. The absence of portal fibrosis in S. mekongi infection allows schistosome eggs to infiltrate into the intralobular area continuously, which can be what lies behind the ultrasonographic differences; the echogenic network pattern as was seen in S. japonicum infection, has not been noted in S. mekongi infection.

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