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Tytuł pozycji:

Epidemiology of methicillin-susceptible Staphylococcus aureus lineages in five major African towns: high prevalence of Panton-Valentine leukocidin genes.

Tytuł:
Epidemiology of methicillin-susceptible Staphylococcus aureus lineages in five major African towns: high prevalence of Panton-Valentine leukocidin genes.
Autorzy:
Breurec S; Institut Pasteur, Dakar, Senegal. />Fall C
Pouillot R
Boisier P
Brisse S
Diene-Sarr F
Djibo S
Etienne J
Fonkoua MC
Perrier-Gros-Claude JD
Ramarokoto CE
Randrianirina F
Thiberge JM
Zriouil SB
Garin B
Laurent F
Corporate Authors:
Working Group on Staphylococcus aureus Infections
Źródło:
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases [Clin Microbiol Infect] 2011 Apr; Vol. 17 (4), pp. 633-9.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
Język:
English
Imprint Name(s):
Publication: 2015- : London : Elsevier
Original Publication: Paris : Decker Europe, c1995-
MeSH Terms:
Anti-Bacterial Agents/*pharmacology
Bacterial Toxins/*genetics
Exotoxins/*genetics
Leukocidins/*genetics
Methicillin/*pharmacology
Staphylococcal Infections/*epidemiology
Staphylococcal Infections/*microbiology
Staphylococcus aureus/*isolation & purification
Virulence Factors/*genetics
Adolescent ; Adult ; Africa/epidemiology ; Aged ; Aged, 80 and over ; Bacterial Typing Techniques ; Child ; Child, Preschool ; Cluster Analysis ; Female ; Genotype ; Humans ; Infant ; Male ; Microbial Sensitivity Tests ; Middle Aged ; Molecular Epidemiology ; Multilocus Sequence Typing ; Prevalence ; Staphylococcus aureus/classification ; Staphylococcus aureus/genetics ; Young Adult
Substance Nomenclature:
0 (Anti-Bacterial Agents)
0 (Bacterial Toxins)
0 (Exotoxins)
0 (Leukocidins)
0 (Panton-Valentine leukocidin)
0 (Virulence Factors)
Q91FH1328A (Methicillin)
Entry Date(s):
Date Created: 20100803 Date Completed: 20110715 Latest Revision: 20220321
Update Code:
20240104
DOI:
10.1111/j.1469-0691.2010.03320.x
PMID:
20673269
Czasopismo naukowe
The epidemiology of methicillin-susceptible Staphylococcus aureus (MSSA) in Africa is poorly documented. From January 2007 to March 2008, 555 S. aureus isolates were collected from five African towns in Cameroon, Madagascar, Morocco, Niger, and Senegal; among these, 456 unique isolates were susceptible to methicillin. Approximately 50% of the MSSA isolates from each different participating centre were randomly selected for further molecular analysis. Of the 228 isolates investigated, 132 (58%) belonged to five major multilocus sequence typing (MLST) clonal complexes (CCs) (CC1, CC15, CC30, CC121 and CC152) that were not related to any successful methicillin-resistant S. aureus (MRSA) clones previously identified in the same study population. The luk-PV genes encoding Panton-Valentine leukocidin (PVL), present in 130 isolates overall (57%), were highly prevalent in isolates from Cameroon, Niger, and Senegal (West and Central Africa). This finding is of major concern, with regard to both a source of severe infections and a potential reservoir for PVL genes. This overrepresentation of PVL in MSSA could lead to the emergence and spread of successful, highly virulent PVL-positive MRSA clones, a phenomenon that has already started in Africa.
(© 2010 The Authors. Clinical Microbiology and Infection © 2010 European Society of Clinical Microbiology and Infectious Diseases.)

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