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Tytuł pozycji:

MT1-MMP plays an important role in an invasive activity of malignant pleural mesothelioma cell.

Tytuł :
MT1-MMP plays an important role in an invasive activity of malignant pleural mesothelioma cell.
Autorzy :
Doi T; Division of Thoracic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Maniwa Y
Tanaka Y
Tane S
Hashimoto S
Ohno Y
Nishio W
Nishimura Y
Ohbayashi C
Okita Y
Hayashi Y
Yoshimura M
Pokaż więcej
Źródło :
Experimental and molecular pathology [Exp Mol Pathol] 2011 Feb; Vol. 90 (1), pp. 91-6. Date of Electronic Publication: 2010 Oct 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Język :
English
Imprint Name(s) :
Publication: <2000- > : Amsteram : Elsevier
Original Publication: New York : Academic Press
MeSH Terms :
Matrix Metalloproteinase 14/*physiology
Mesothelioma/*genetics
Pleural Neoplasms/*genetics
Cell Line, Tumor ; Cell Movement/genetics ; Gene Knockdown Techniques ; Humans ; Matrix Metalloproteinase 14/genetics ; Neoplasm Invasiveness/pathology ; RNA Interference
Substance Nomenclature :
EC 3.4.24.80 (Matrix Metalloproteinase 14)
Entry Date(s) :
Date Created: 20101026 Date Completed: 20110211 Latest Revision: 20110103
Update Code :
20210210
DOI :
10.1016/j.yexmp.2010.10.008
PMID :
20969861
Czasopismo naukowe
Malignant pleural mesothelioma (MPM) has a poor prognosis and is a treatment resistant tumor, which is increasing in frequency throughout the world. The poor prognosis is due to the aggressive local invasiveness rather than distant metastasis. In this study, we established a cell line of malignant mesothelioma from a clinical specimen and assessed the relationship between the expression of MT1-MMP and the invasion ability of that line, as well as the cultured cells of several other lines, using the simple method that we created previously. We established a cell line from a clinical specimen from a patient with malignant mesothelioma. We assessed the invasive activities of MPM cells in an easy-to-prepare double-layered collagen gel hemisphere (DL-CGH) system that enabled us to visualize cell movements during invasion. To assess the role of MT1-MMP in the invasive activity of MPM cells, we knocked down its expression by RNA interference (RNAi). The invasion assay with DL-CGH revealed that a high expression of MT1-MMP in MPM cells was associated with aggressive invasive activity. The RNAi of MT1-MMP indicated that the expression of MT1-MMP might have a crucial role in the invasiveness of MPM cells. The MT1-MMP expression in MPM cells is related to their capacity for locally aggressive spreading into the pleura and the surrounding tissues, and MT1-MMP should be a suitable molecular target for the suppression of the invasiveness of MPM.
(Copyright © 2010 Elsevier Inc. All rights reserved.)

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