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Tytuł:
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Glut4 is upregulated despite decreased insulin signaling during prolonged fasting in northern elephant seal pups.
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Autorzy:
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Viscarra JA; University of California, Merced, 95343, USA. />Vázquez-Medina JP
Crocker DE
Ortiz RM
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Źródło:
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American journal of physiology. Regulatory, integrative and comparative physiology [Am J Physiol Regul Integr Comp Physiol] 2011 Jan; Vol. 300 (1), pp. R150-4. Date of Electronic Publication: 2010 Oct 27.
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Typ publikacji:
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Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Original Publication: Bethesda, Md. : American Physiological Society
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MeSH Terms:
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Fasting/*metabolism
Glucose Transporter Type 4/*metabolism
Insulin/*metabolism
Seals, Earless/*metabolism
Signal Transduction/*physiology
Up-Regulation/*physiology
Adiponectin/blood ; Adipose Tissue/metabolism ; Animals ; Animals, Newborn/metabolism ; Blood Glucose/metabolism ; Hydrocortisone/blood ; Insulin Resistance/physiology ; Models, Animal ; Muscle, Skeletal/metabolism
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References:
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Am J Physiol. 1982 May;242(5):R591-5. (PMID: 7081482)
J Exp Biol. 2008 Sep;211(Pt 18):2943-9. (PMID: 18775931)
J Endocrinol Invest. 2011 Feb;34(2):e16-23. (PMID: 20651470)
Am J Physiol Regul Integr Comp Physiol. 2007 Dec;293(6):R2376-81. (PMID: 17913869)
J Clin Invest. 1997 Oct 15;100(8):2094-8. (PMID: 9329975)
Horm Metab Res. 1979 Oct;11(10):555-60. (PMID: 391689)
Physiol Rev. 1998 Jul;78(3):783-809. (PMID: 9674695)
J Clin Invest. 1997 Feb 1;99(3):414-23. (PMID: 9022074)
Am J Physiol. 1985 Oct;249(4 Pt 2):R462-70. (PMID: 4051032)
Physiol Zool. 1998 Sep-Oct;71(5):485-91. (PMID: 9754525)
J Biol Chem. 1995 Oct 13;270(41):24442-50. (PMID: 7592659)
Clin Sci (Lond). 2001 Dec;101(6):739-47. (PMID: 11724664)
J Biol Chem. 1997 Feb 7;272(6):3216-22. (PMID: 9013557)
J Biol Chem. 2000 Nov 10;275(45):34841-4. (PMID: 10973946)
Annu Rev Nutr. 1995;15:441-71. (PMID: 8527229)
J Endocrinol. 2010 Jan;204(1):1-11. (PMID: 19770178)
Endocrinology. 1997 Oct;138(10):4338-45. (PMID: 9322948)
J Endocrinol. 2009 Oct;203(1):1-18. (PMID: 19389739)
Diab Vasc Dis Res. 2010 Jan;7(1):56-62. (PMID: 20368233)
Am J Physiol. 1992 Oct;263(4 Pt 1):E663-6. (PMID: 1384356)
Diabetologia. 2010 Sep;53(9):2008-19. (PMID: 20490453)
Diabetes Res Clin Pract. 2008 Aug;81(2):144-9. (PMID: 18562038)
Biochem Biophys Res Commun. 1985 Dec 17;133(2):696-701. (PMID: 3002352)
J Comp Physiol B. 1987;157(4):445-9. (PMID: 3668021)
Am J Physiol Endocrinol Metab. 2005 Oct;289(4):E643-9. (PMID: 15928020)
J Clin Endocrinol Metab. 2008 Feb;93(2):638-41. (PMID: 18056775)
J Endocrinol. 2003 Sep;178(3):533-9. (PMID: 12967344)
Mol Cell Biochem. 2010 Nov;344(1-2):151-62. (PMID: 20617369)
J Exp Biol. 2005 Mar;208(Pt 5):859-68. (PMID: 15755884)
Am J Physiol. 1996 Jan;270(1 Pt 1):E36-42. (PMID: 8772471)
Eur J Clin Invest. 2009 Feb;39(2):81-93. (PMID: 19200161)
Metabolism. 1987 Jul;36(7):692-6. (PMID: 3298937)
Diabetologia. 1998 Jun;41(6):634-9. (PMID: 9662043)
Am J Physiol Regul Integr Comp Physiol. 2001 Mar;280(3):R790-5. (PMID: 11171659)
Endocrinology. 1980 Feb;106(2):547-52. (PMID: 6986256)
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Grant Information:
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R01 HL091767 United States HL NHLBI NIH HHS; HL-091767 United States HL NHLBI NIH HHS
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Substance Nomenclature:
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0 (Adiponectin)
0 (Blood Glucose)
0 (Glucose Transporter Type 4)
0 (Insulin)
WI4X0X7BPJ (Hydrocortisone)
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Entry Date(s):
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Date Created: 20101029 Date Completed: 20110120 Latest Revision: 20211020
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Update Code:
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20240104
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PubMed Central ID:
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PMC3023278
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DOI:
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10.1152/ajpregu.00478.2010
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PMID:
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20980624
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Postprandial cellular glucose uptake is dependent on an insulin-signaling cascade in muscle and adipose tissue, resulting in the translocation of the insulin-dependent glucose transporter 4 (Glut4) into the plasma membrane. Additionally, extended food deprivation is characterized by suppressed insulin signaling and decreased Glut4 expression. Northern elephant seals are adapted to prolonged fasts characterized by high levels of plasma glucose. To address the hypothesis that the fasting-induced decrease in insulin is associated with reduced insulin signaling in prolonged fasted seals, we compared the adipose protein levels of the cellular insulin-signaling pathway, Glut4 and plasma glucose, insulin, cortisol, and adiponectin concentrations between Early (n = 9; 2-3 wks postweaning) and Late (n = 8; 6-8 wks postweaning) fasted seals. Plasma adiponectin (230 ± 13 vs. 177 ± 11 ng/ml), insulin (2.7 ± 0.4 vs. 1.0 ± 0.1 μU/ml), and glucose (9.8 ± 0.5 vs. 8.0 ± 0.3 mM) decreased, while cortisol (124 ± 6 vs. 257 ± 30 nM) doubled with fasting. Glut4 increased (31%) with fasting despite the significant decreases in the cellular content of phosphatidylinositol 3-kinase as well as phosphorylated insulin receptor, insulin receptor substrate-1, and Akt2. Increased Glut4 may have contributed to the decrease in plasma glucose, but the decrease in insulin and insulin signaling suggests that Glut4 is not insulin-dependent in adipose tissue during prolonged fasting in elephant seals. The reduction of plasma glucose independent of insulin may make these animals an ideal model for the study of insulin resistance.