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Tytuł pozycji:

Analysis of the rat skin permeation of hydrophilic compounds using the Renkin function.

Tytuł:
Analysis of the rat skin permeation of hydrophilic compounds using the Renkin function.
Autorzy:
Seki T; Faculty of Pharmaceutical Sciences, Josai University, 1–1 Keyakidai, Sakado, Saitama 350–0295, Japan. />Kiuchi T
Seto H
Kimura S
Egawa Y
Ueda H
Morimoto Y
Źródło:
Biological & pharmaceutical bulletin [Biol Pharm Bull] 2010; Vol. 33 (11), pp. 1915-8.
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Original Publication: Tokyo : Pharmaceutical Society of Japan, c1993-
MeSH Terms:
Skin Absorption*
Chemistry, Pharmaceutical/*methods
Animals ; Drug Administration Routes ; Hydrophobic and Hydrophilic Interactions ; Lipids ; Male ; Mathematics ; Oligosaccharides/pharmacokinetics ; Permeability ; Rats ; Rats, Hairless ; Solutions ; Sugar Alcohols/pharmacokinetics ; Water
Substance Nomenclature:
0 (Lipids)
0 (Oligosaccharides)
0 (Solutions)
0 (Sugar Alcohols)
059QF0KO0R (Water)
Entry Date(s):
Date Created: 20101105 Date Completed: 20110629 Latest Revision: 20190720
Update Code:
20240104
DOI:
10.1248/bpb.33.1915
PMID:
21048322
Czasopismo naukowe
The Renkin function was applied to characterize the penetration pathways through rat skin following different pretreatments. Nonmetabolic oligosaccharides and sugar alcohols, as model hydrophilic compounds, were applied simultaneously to the excised skin to obtain the equivalent cylindrical pore radius (R) and pore occupancy/length ratio (ε/L) for each skin piece. The R and ε/L values obtained were used to construct the simulation curves of the permeability coefficient (P(a))-molecular weight (MW). In the case of full-stripped skin, the P(a) of the model compounds and separately obtained P(a) of 5(6)-carboxyfluorescein (CF) showed good agreement with the simulation curve based on the Renkin function, suggesting that the viable epidermis and dermis in the full-stripped skin contained permeation pathways for hydrophilic compounds like aqueous channels. On the other hand, there was poor agreement of P(a) with the simulation curve for skin pretreated with an ethanol-menthol mixed enhancer system and the observed P(a) of CF in the pretreated skin was twice that calculated. The enhancer system might not be able to create aqueous channels in the lipid layer of the stratum corneum and could increase the permeation of CF in the layer in a different way. The analysis presented here will be useful not only for quantitative evaluation of drug permeation through aqueous channels in treated skins but also for investigation of the mechanism of skin-permeation enhancing techniques.

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