[Investigation on representation methods of dissolubility property of total alkaloid extract from Peganum harmala].

Szczegóły
Abstrakt

Tytuł:: [Investigation on representation methods of dissolubility property of total alkaloid extract from Peganum harmala].
Autorzy:: Ding K; Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, China.
Liu L
Cheng X
Wang C
Wang Z
Źródło:: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica [Zhongguo Zhong Yao Za Zhi] 2010 Sep; Vol. 35 (17), pp. 2250-3.
Typ publikacji:: Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't
Język:: Chinese
Imprint Name(s):: Publication: Beijing : Zhongguo yao xue hui : Zhongguo Zhong yi yan jiu yuan Zhong yao yan jiu suo
Original Publication: [Beijing] : Zhongguo yao xue hui : [Zhongguo Zhong yi yan jiu yuan Zhong yao yan jiu suo, 1989-
MeSH Terms:: Alkaloids/*chemistry
Chemical Fractionation/*methods
Peganum/*chemistry
Plant Extracts/*chemistry
Alkaloids/isolation & purification ; Particle Size ; Plant Extracts/isolation & purification ; Solubility ; Solvents/chemistry
Substance Nomenclature:: 0 (Alkaloids)
0 (Plant Extracts)
0 (Solvents)
Entry Date(s):: Date Created: 20101209 Date Completed: 20110110 Latest Revision: 20191210
Update Code:: 20240104
PMID:: 21137330
: Czasopismo naukowe

Objective: To investigate the representation methods of dissolubility property of total alkaloid extract from Peganum hamala in different solvents, and to investigate the evaluation method of the dissolubility property of extracts from traditional Chinese medicine.
Method: The dissolubility property of the whole extract and markers of harmaline and harmine, as well as the particle diameter distribution of the extract in different solvents were evaluated by precipitation method, solubility test, and the particle diameter test.
Result: Both the alkaloid extract and it's index ingredients had good solubility in absolute ethanol, 95% ethanol, and 80% ethanol, while the solubility in 60% ethanol was poor, and worst in water. The sequence of particle diameter of extract in solvents was in the following order water > 95% ethanol > 60% ethanol > 60% ethanol > 80% ethanol.
Conclusion: The extract has good solubility in the ethanol solution whose concentration is over 80%. The results between precipitation method and index components method have certain correlation. The particle diameter method can provide distribution information of the extract in different solvents. Combination of those three methods could reflect the dissolubility property of extracts from traditional Chinese medicine more comprehensively.

Informacja