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Tytuł pozycji:

[Determinants of resistance to chlortetracycline and other antibiotics in chlortetracycline-producing strain of Streptomyces aureofaciens].

Tytuł :
[Determinants of resistance to chlortetracycline and other antibiotics in chlortetracycline-producing strain of Streptomyces aureofaciens].
Autorzy :
Chinenova TA
Biriukova IV
Voeĭkova TA
Emel'ianova LK
Klochkova OA
Sezonov GV
Lomovskaia ND
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Transliterated Title :
Determinanty ustoĭchivosti k khlortetratsiklinu i drugim antibiotikam u shtamma Streptomyces aureofaciens--produtsenta khlortetratsiklina.
Źródło :
Genetika [Genetika] 1990 Apr; Vol. 26 (4), pp. 636-47.
Typ publikacji :
English Abstract; Journal Article
Język :
Russian
Imprint Name(s) :
Original Publication: Moskva : Izdatelstvo Nauka
MeSH Terms :
Chlortetracycline/*biosynthesis
Drug Resistance, Microbial/*genetics
Streptomyces aureofaciens/*genetics
Tetracycline Resistance/*genetics
Chlortetracycline/pharmacology ; DNA, Bacterial/genetics ; Genes, Bacterial ; Mutation ; Streptomyces aureofaciens/drug effects ; Streptomyces aureofaciens/metabolism
Substance Nomenclature :
0 (DNA, Bacterial)
WCK1KIQ23Q (Chlortetracycline)
Entry Date(s) :
Date Created: 19900401 Date Completed: 19900829 Latest Revision: 20131121
Update Code :
20201218
PMID :
2115485
Czasopismo naukowe
Data are presented on resistance of Streptomyces aureofaciens strain TB-633 FU--the producer of chlortetracycline (CTC) to autogenous antibiotics and a number of other antibiotics. It is demonstrated that resistance to CTC is specified by ctr genes of constitutive expression as well as by inducible genes. CTC and ethidium bromide may serve as efficient inductors of inducible ctr genes. The induction process is accompanied by increase in antibiotic biosynthesis level. Genes responsible for strain resistance to a number of macrolide antibiotics and thiostrepton are inducible and only function in the presence of appropriate antibiotics in the medium. The action of inducible mtr gene(s) is described in detail. The gene(s) simultaneously ensure increase in resistance to CTC and a number of macrolide antibiotics in the presence of exogenous inductors in media, such as both CTC and macrolide antibiotics. Mutants have been isolated which provide constitutive level of resistance to these antibiotics. A series of ctr and mtr mutants have increased CTC biosynthesis as compared to the initial level. Data on comparative analysis of the results obtained from hybridization of fragments of S. aureofaciens and S. rimosus DNAs to actI and actIII genes, responsible for polyketide synthases' synthesis, demonstrate that genes for CTC and OTC biosynthesis are situated on DNA fragments of similar size. This determines the strategy for cloning ctr and mtr genes as well as genes for CTC biosynthesis from S. aureofaciens.

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