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Tytuł:
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Acute myeloid leukemia associated with t(1;3)(p36;q21) and extreme thrombocytosis: a clinical study with literature review.
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Autorzy:
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Lim G; Department of Laboratory Medicine, School of Medicine, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-702, Korea.
Kim MJ
Oh SH
Cho SY
Lee HJ
Suh JT
Lee J
Lee WI
Cho KS
Park TS
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Źródło:
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Cancer genetics and cytogenetics [Cancer Genet Cytogenet] 2010 Dec; Vol. 203 (2), pp. 187-92.
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Typ publikacji:
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Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review
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Język:
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English
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Imprint Name(s):
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Original Publication: [New York] Elsevier/North-Holland.
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MeSH Terms:
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Chromosomes, Human, Pair 1*
Chromosomes, Human, Pair 3*
Translocation, Genetic*
Leukemia, Myeloid, Acute/*genetics
Thrombocytosis/*genetics
Adult ; Aged ; Bone Marrow Cells/cytology ; Female ; Humans ; In Situ Hybridization, Fluorescence ; Karyotyping ; Male ; Middle Aged
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Entry Date(s):
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Date Created: 20101216 Date Completed: 20110104 Latest Revision: 20101215
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Update Code:
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20240104
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DOI:
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10.1016/j.cancergencyto.2010.08.001
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PMID:
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21156232
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We present an unusual case study on acute myeloid leukemia associated with t(1;3) and extreme thrombocytosis, along with a thorough review on relevant literature of t(1;3) cases (58 patients). On the basis of this study and literature review, thrombocytosis (>400,000/μL) is a relatively common finding in one third of patients with t(1;3), whereas increase of platelet count by more than 1,000,000/μL is an extremely rare phenomenon, even among patients with t(1;3). To our knowledge, this study is the only documented case that recorded more than 2,000,000/μL of extreme thrombocytosis in a de novo acute myeloid leukemia patient with t(1;3) at initial diagnosis. Because only a few patients with t(1;3) responded to conventional chemotherapy, more aggressive therapy such as stem-cell transplantation should be considered to improve patient survival in t(1;3) cases.
(Copyright © 2010 Elsevier Inc. All rights reserved.)