Thyroid hormones affect plasma ghrelin and obestatin levels.

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Abstrakt

Tytuł:: Thyroid hormones affect plasma ghrelin and obestatin levels.
Autorzy:: Kosowicz J; Department of Endocrinology and Metabolism, Poznan University of Medical Sciences, Poznan, Poland. />Baumann-Antczak A
Ruchała M
Gryczyñska M
Gurgul E
Sowiñski J
Źródło:: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme [Horm Metab Res] 2011 Feb; Vol. 43 (2), pp. 121-5. Date of Electronic Publication: 2010 Dec 16.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Original Publication: Stuttgart, Thieme.
MeSH Terms:: Ghrelin/*blood
Hypothyroidism/*blood
Thyroid Hormones/*blood
Thyrotoxicosis/*blood
Adult ; Female ; Humans ; Male ; Middle Aged
Substance Nomenclature:: 0 (Ghrelin)
0 (Thyroid Hormones)
Entry Date(s):: Date Created: 20101218 Date Completed: 20110524 Latest Revision: 20110202
Update Code:: 20240104
DOI:: 10.1055/s-0030-1269853
PMID:: 21165813
: Czasopismo naukowe

Using radioimmunoassay, the effects of thyroid hormones on plasma total ghrelin (Gh) and obestatin (Ob) concentrations were evaluated in thyrotoxic patients with an excess of thyroid hormones and in hypothyroid patients lacking endogenous thyroid hormones. 24 patients with thyrotoxicosis, 25 hypothyroid patents after total thyreoidectomy performed due to thyroid cancer, and 17 control subjects were examined. Compared with the controls, the ghrelin and obestatin were elevated in hypothyroidism, while they were decreased in thyrotoxicosis. The plasma Gh and Ob levels differ depending on the thyroid function. In thyroid hormones deficiency, plasma Gh and Ob are increased, while in patients with excess of thyroid hormones, the levels of both Gh and Ob are definitely lower. Gh/Ob ratio is higher in hypothyroidism than in control subjects and thyrotoxic patients.
(© Georg Thieme Verlag KG Stuttgart · New York.)

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