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Tytuł:
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Novel ovarian regulatory peptides: inhibin, activin, and follistatin.
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Autorzy:
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Ling N; Department of Molecular Endocrinology, Whittier Institute for Diabetes and Endocrinology, La Jolla, CA 92037.
DePaolo LV
Bicsak TA
Shimasaki S
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Źródło:
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Clinical obstetrics and gynecology [Clin Obstet Gynecol] 1990 Sep; Vol. 33 (3), pp. 690-702.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review
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Język:
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English
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Imprint Name(s):
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Publication: Hagerstown, MD : Lippincott Williams & Wilkins
Original Publication: Hagerstown [Md., etc.] Harper & Row.
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MeSH Terms:
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Glycoproteins*/chemistry
Glycoproteins*/isolation & purification
Glycoproteins*/physiology
Inhibins*/chemistry
Inhibins*/isolation & purification
Inhibins*/physiology
Ovary/*chemistry
Activins ; Amino Acid Sequence ; Animals ; Female ; Follicle Stimulating Hormone/metabolism ; Follistatin ; Humans ; Molecular Sequence Data
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Liczba referencji:
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24
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Grant Information:
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DK-18811 United States DK NIDDK NIH HHS; HD-09690 United States HD NICHD NIH HHS; N01-HD-6-2944 United States HD NICHD NIH HHS
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Substance Nomenclature:
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0 (Follistatin)
0 (Glycoproteins)
104625-48-1 (Activins)
57285-09-3 (Inhibins)
9002-68-0 (Follicle Stimulating Hormone)
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Entry Date(s):
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Date Created: 19900901 Date Completed: 19901221 Latest Revision: 20190828
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Update Code:
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20240104
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DOI:
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10.1097/00003081-199009000-00031
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PMID:
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2121404
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Based on the extensive amount of research on inhibin and related polypeptides accomplished during the past 5 years, the inhibin concept put forth more than 50 years ago has not only become well established but also more complex than originally imagined. The closed-loop feedback mechanism of ovarian inhibin and pituitary FSH has been joined by possible "inhibin-like" actions of follistatin and FSH-stimulatory effects of activin. In addition, in vitro experiments suggest possible autocrine and paracrine functions for the gonadal polypeptide hormones. Figure 3 shows a simplistic diagram summarizing our current understanding of inhibin/activin and follistatin action along the hypothalamic-pituitary-gonadal axis. Hopefully, research in the coming years will allow us to remove the many question marks still remaining but will undoubtedly add others.