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Tytuł pozycji:

Analysis of risk factors for a high prevalence of extended-spectrum {beta}-lactamase-producing Enterobacteriaceae in asymptomatic individuals in rural Thailand.

Tytuł:
Analysis of risk factors for a high prevalence of extended-spectrum {beta}-lactamase-producing Enterobacteriaceae in asymptomatic individuals in rural Thailand.
Autorzy:
Luvsansharav UO; Department of Bioinformatics, Osaka University Graduate School of Medicine, Osaka, Japan.
Hirai I; International Center for Medical Research and Treatment, Kobe University Graduate School of Medicine, Kobe, Japan.; Department of Bioinformatics, Osaka University Graduate School of Medicine, Osaka, Japan.
Niki M; Department of Bioinformatics, Osaka University Graduate School of Medicine, Osaka, Japan.
Sasaki T; Department of Bioinformatics, Osaka University Graduate School of Medicine, Osaka, Japan.
Makimoto K; Department of Nursing, Osaka University Graduate School of Medicine, Osaka, Japan.
Komalamisra C; Department of Helminthology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Maipanich W; Department of Helminthology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Kusolsuk T; Department of Helminthology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Sa-Nguankiat S; Department of Helminthology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Pubampen S; Department of Helminthology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Yamamoto Y; International Center for Medical Research and Treatment, Kobe University Graduate School of Medicine, Kobe, Japan.; Department of Bioinformatics, Osaka University Graduate School of Medicine, Osaka, Japan.
Źródło:
Journal of medical microbiology [J Med Microbiol] 2011 May; Vol. 60 (Pt 5), pp. 619-624. Date of Electronic Publication: 2011 Feb 03.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
Język:
English
Imprint Name(s):
Publication: 2015- : London : Microbiology Society
Original Publication: 1968-1995: Edinburgh, Livingstone.
MeSH Terms:
Enterobacteriaceae/*enzymology
Enterobacteriaceae/*isolation & purification
Enterobacteriaceae Infections/*epidemiology
beta-Lactamases/*biosynthesis
Adult ; Aged ; Aged, 80 and over ; Anti-Bacterial Agents/adverse effects ; Asymptomatic Infections/epidemiology ; Base Sequence ; DNA, Bacterial/genetics ; DNA, Bacterial/isolation & purification ; Enterobacteriaceae/classification ; Enterobacteriaceae/genetics ; Enterobacteriaceae Infections/microbiology ; Feces/microbiology ; Female ; Genes, Bacterial ; Humans ; Male ; Middle Aged ; Prevalence ; Risk Factors ; Rural Population ; Thailand/epidemiology ; beta-Lactamases/genetics
Substance Nomenclature:
0 (Anti-Bacterial Agents)
0 (DNA, Bacterial)
EC 3.5.2.6 (beta-Lactamases)
Entry Date(s):
Date Created: 20110205 Date Completed: 20110701 Latest Revision: 20200403
Update Code:
20240104
DOI:
10.1099/jmm.0.026955-0
PMID:
21292857
Czasopismo naukowe
The prevalence of and risk factors associated with extended-spectrum β-lactamase (ESBL)-producing micro-organisms have not been well studied in healthy individuals. The aim of this study was to determine this in healthy individuals in Thailand. Stool samples and questionnaires obtained from 445 participants from three provinces in Thailand were analysed. The antimicrobial susceptibility of the isolates was assessed using phenotypic and genotypic methods. PCR analysis was performed to detect and group the bla(CTX-M) genes. The prevalence of CTX-M-type ESBL-producing Enterobacteriaceae in the three provinces was as follows: 29.3 % in Nan (43/147), 29.9 % in Nakhon Si Thammarat (43/144) and 50.6 % in Kanchanaburi (78/154) (P<0.001). Of the 445 samples, 33 (7.4 %), 1 (0.2 %) and 127 (28.5 %) isolates belonged to the bla(CTX-M) gene groups I, III and IV, respectively. Escherichia coli was the predominant member of the Enterobacteriaceae producing CTX-M-type ESBLs (40/43, 39/43 and 70/78 isolates in Nan, Nakhon Si Thammarat and Kanchanaburi, respectively). No statistically significant association was observed between the presence of ESBL-producing bacteria and gender, age, education, food habits or antibiotic usage. However, the provinces that had the highest prevalence of ESBL-producing Enterobacteriaceae also had the highest prevalence of use and purchase of antibiotics without a prescription. Thus, this study revealed that faecal carriage of ESBL-producing Enterobacteriaceae is very high in asymptomatic individuals in Thailand, with some variations among the provinces. This high prevalence may be linked to antibiotic abuse.

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