Different transcriptional profiles of human monocyte-derived dendritic cells infected with distinct strains of Mycobacterium tuberculosis and Mycobacterium bovis bacillus Calmette-Guérin.

Szczegóły
Abstrakt

Tytuł:: Different transcriptional profiles of human monocyte-derived dendritic cells infected with distinct strains of Mycobacterium tuberculosis and Mycobacterium bovis bacillus Calmette-Guérin.
Autorzy:: Sanarico N; Institute of Cell Biology and Neurobiology, National Research Council, Rome, Italy. />Colone A
Grassi M
Speranza V
Giovannini D
Ciaramella A
Colizzi V
Mariani F
Źródło:: Clinical & developmental immunology [Clin Dev Immunol] 2011; Vol. 2011, pp. 741051. Date of Electronic Publication: 2011 Mar 22.
Typ publikacji:: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Publication: 2007- : Cario : Hindawi Pub. Corporation
Original Publication: 2003-2006: Abingdon, U.K. : Taylor & Francis Health Sciences
MeSH Terms:: Tuberculosis Vaccines*
Dendritic Cells/*metabolism
Mycobacterium bovis/*immunology
Mycobacterium tuberculosis/*immunology
Tuberculosis/*immunology
Dendritic Cells/immunology ; Dendritic Cells/microbiology ; Dendritic Cells/pathology ; Gene Expression Profiling ; Humans ; Immunophenotyping ; Interleukin-10/genetics ; Interleukin-10/metabolism ; Interleukins/genetics ; Interleukins/metabolism ; Minor Histocompatibility Antigens ; Monocytes/pathology ; Mycobacterium bovis/pathogenicity ; Mycobacterium tuberculosis/pathogenicity ; Receptors, CCR7/genetics ; Receptors, CCR7/metabolism ; Species Specificity ; Tuberculosis/microbiology ; Tuberculosis/prevention & control ; Tumor Necrosis Factor-alpha/genetics ; Tumor Necrosis Factor-alpha/metabolism ; Virulence
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Substance Nomenclature:: 0 (CCR7 protein, human)
0 (EBI3 protein, human)
0 (Interleukins)
0 (Minor Histocompatibility Antigens)
0 (Receptors, CCR7)
0 (Tuberculosis Vaccines)
0 (Tumor Necrosis Factor-alpha)
130068-27-8 (Interleukin-10)
Entry Date(s):: Date Created: 20110326 Date Completed: 20110718 Latest Revision: 20211020
Update Code:: 20240104
PubMed Central ID:: PMC3062957
DOI:: 10.1155/2011/741051
PMID:: 21436989
: Czasopismo naukowe

Pełny tekst

In order to analyze dendritic cells (DCs) activation following infection with different mycobacterial strains, we studied the expression profiles of 165 genes of human monocyte-derived DCs infected with H37Rv, a virulent Mycobacterium tuberculosis (MTB) laboratory strain, CMT97, a clinical MTB isolate, Mycobacterium bovis bacillus Calmette-Guérin (BCG), Aventis Pasteur, and BCG Japan, both employed as vaccine against tuberculosis. The analysis of the gene expression reveals that, despite a set of genes similarly modulated, DCs response resulted strain dependent. In particular, H37Rv significantly upregulated EBI3 expression compared with BCG Japan, while it was the only strain that failed to release a significant IL-10 amount. Of note, BCG Japan showed a marked increase in CCR7 and TNF-α expression regarding both MTB strains and it resulted the only strain failing in exponential intracellular growth. Our results suggest that DCs display the ability to elicit a tailored strain-specific immune response.

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