Does surgery or radiation therapy impact survival for patients with extrapulmonary small cell cancers?

Tytuł:: Does surgery or radiation therapy impact survival for patients with extrapulmonary small cell cancers?
Autorzy:: Grossman RA; Sylvester Comprehensive Cancer Center, Division of Surgical Oncology, DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA.
Pedroso FE
Byrne MM
Koniaris LG
Misra S
Źródło:: Journal of surgical oncology [J Surg Oncol] 2011 Nov 01; Vol. 104 (6), pp. 604-12. Date of Electronic Publication: 2011 May 25.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Publication: <2005-> : Hoboken, NJ : Wiley-Liss
Original Publication: New York, Plenum.
MeSH Terms:: Brachytherapy*
Breast Neoplasms/*mortality
Gastrointestinal Neoplasms/*mortality
Head and Neck Neoplasms/*mortality
Lung Neoplasms/*mortality
Small Cell Lung Carcinoma/*mortality
Urogenital Neoplasms/*mortality
Aged ; Breast Neoplasms/radiotherapy ; Breast Neoplasms/secondary ; Breast Neoplasms/surgery ; Combined Modality Therapy ; Female ; Follow-Up Studies ; Gastrointestinal Neoplasms/radiotherapy ; Gastrointestinal Neoplasms/secondary ; Gastrointestinal Neoplasms/surgery ; Head and Neck Neoplasms/radiotherapy ; Head and Neck Neoplasms/secondary ; Head and Neck Neoplasms/surgery ; Humans ; Lung Neoplasms/pathology ; Lung Neoplasms/radiotherapy ; Lung Neoplasms/surgery ; Male ; Small Cell Lung Carcinoma/radiotherapy ; Small Cell Lung Carcinoma/secondary ; Small Cell Lung Carcinoma/surgery ; Survival Rate ; Treatment Outcome ; Urogenital Neoplasms/radiotherapy ; Urogenital Neoplasms/secondary ; Urogenital Neoplasms/surgery
Entry Date(s):: Date Created: 20110528 Date Completed: 20111129 Latest Revision: 20170916
Update Code:: 20240104
DOI:: 10.1002/jso.21976
PMID:: 21618245
: Czasopismo naukowe

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Background and Objectives: Extrapulmonary small cell carcinomas (EPSCC) are rare tumors where therapy remains poorly defined. We sought to determine the impact of surgical extirpation and radiation therapy for outcomes of EPSCC.
Methods: The Surveillance, Epidemiology, and End Results (SEER) database was queried for patients with EPSCC which were further categorized by site and evaluated for survival by specific treatment strategy.
Results: We identified 94,173 patients with small cell carcinoma of which 88,605 (94.1%) and 5,568 (5.9%) had pulmonary small cell carcinoma and EPSCC, respectively. EPSCC patients were subdivided by site with the following proportions: genitourinary (24.1%), gastrointestinal (22.1%), head and neck (7.1%), breast (4%), and miscellaneous (42.7%). Overall EPSSC and specifically gastrointestinal disease had significantly improved median, 5- and 10-year survival with surgery and/or radiation for all stages and sizes. For all EPSCCs multivariate analysis revealed age (>50), gender (female), stage (regional, distant), radiation, and surgery to be independent predictors of survival.
Conclusions: Although outcomes for EPSCC remains poor, both surgery and radiation is shown to significantly improve median, 5- and 10-year survival rates. EPSCC patients who are potential candidates for surgical resection or radiation therapy may benefit from these treatments.
(Copyright © 2011 Wiley Periodicals, Inc.)

Comment in: Strahlenther Onkol. 2012 Mar;188(3):289-90. (PMID: 22679633)

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