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Tytuł:
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Pharmacokinetics of moxidectin in the southern hairy-nosed wombat (Lasiorhinus latifrons).
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Autorzy:
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Death CE; Conservation Medicine Program, School of Veterinary and Biomedical Sciences, Murdoch University, 90 South Street, Murdoch, Western Australia, 6150, Australia. />Taggart DA
Williams DB
Milne R
Schultz DJ
Holyoake C
Warren KS
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Źródło:
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Journal of wildlife diseases [J Wildl Dis] 2011 Jul; Vol. 47 (3), pp. 643-9.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Publication: Lawrence, KS : Wildlife Disease Association
Original Publication: Ames, Iowa, Wildlife Disease Assn.
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MeSH Terms:
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Anthelmintics/*pharmacokinetics
Marsupialia/*metabolism
Scabies/*veterinary
Animals ; Anthelmintics/administration & dosage ; Area Under Curve ; Australia ; Female ; Half-Life ; Injections, Subcutaneous/veterinary ; Macrolides/administration & dosage ; Macrolides/pharmacokinetics ; Marsupialia/blood ; Scabies/drug therapy
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Substance Nomenclature:
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0 (Anthelmintics)
0 (Macrolides)
NGU5H31YO9 (moxidectin)
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Entry Date(s):
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Date Created: 20110702 Date Completed: 20110915 Latest Revision: 20191210
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Update Code:
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20240104
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DOI:
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10.7589/0090-3558-47.3.643
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PMID:
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21719829
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Sarcoptic mange, caused by Sarcoptes scabiei var. wombati, could be a significant threat to populations of southern hairy-nosed wombats (Lasiorhinus latifrons; SHNW) in Australia. Treatment is currently based on the off-label use of various parasiticidal drugs, with limited clinical efficacy trials. Our primary aim was to determine the pharmacokinetic parameters of a macrocyclic lactone, moxidectin, to assist in the development of effective treatment protocols. Pharmacokinetic parameters were determined in four female SHNW following a single subcutaneous injection of 0.2 mg/kg moxidectin. Blood samples were collected for 38 days following injection (August-September 2008), for analysis using liquid chromatography and tandem mass spectrometry. The mean peak plasma concentration occurred at 13.6 hr, with a mean peak plasma level of 98.6 ng/ml. The mean elimination half-life was 5.03 days, resulting in a mean area under the curve of 377 ng.day/ml. The peak plasma moxidectin concentration was higher than that seen in livestock species but the plasma elimination half-life was shorter. This study suggests that a single injection of 0.2 mg/kg moxidectin may not be sufficient to clear a mange infection in this species.