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Tytuł:
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Rapid enterovirus molecular testing in cerebrospinal fluid reduces length of hospitalization and duration of antibiotic therapy in children with aseptic meningitis.
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Autorzy:
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Huizing KM; Department of Paediatrics, Rijnstate Hospital Arnhem, Arnhem, The Netherlands.
Swanink CM
Landstra AM
van Zwet AA
van Setten PA
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Źródło:
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The Pediatric infectious disease journal [Pediatr Infect Dis J] 2011 Dec; Vol. 30 (12), pp. 1107-9.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: [Baltimore, Md. : Williams & Wilkins, c1987-
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MeSH Terms:
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Anti-Bacterial Agents/*therapeutic use
Enterovirus/*isolation & purification
Meningitis, Aseptic/*cerebrospinal fluid
Meningitis, Aseptic/*virology
Cerebrospinal Fluid/virology ; Child ; Enterovirus/genetics ; Humans ; Length of Stay/statistics & numerical data ; Meningitis, Aseptic/drug therapy ; Molecular Diagnostic Techniques ; Prospective Studies ; Real-Time Polymerase Chain Reaction ; Statistics, Nonparametric ; Virology
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Substance Nomenclature:
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0 (Anti-Bacterial Agents)
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Entry Date(s):
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Date Created: 20110729 Date Completed: 20120525 Latest Revision: 20111122
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Update Code:
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20240104
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DOI:
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10.1097/INF.0b013e31822cca1f
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PMID:
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21796013
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We studied the potential benefits of introducing a rapid enterovirus molecular test in children with enterovirus meningitis. The 2 groups of pediatric patients were comparable with respect to clinical and laboratory data, but differed in availability of enterovirus test results. In the control group, the results were available within 3 to 7 days, whereas in the study group, rapid enterovirus molecular test results were available within 3 to 24 hours. The median duration of hospitalization and the duration of antibiotics were significantly reduced to, respectively, 2 days and 1 day in the study group when compared with the control group (P < 0.001). Mean costs per patient calculation showed an average reduction of more than US $1450 (P < 0.001).