Synthesis, crystal structures, photophysical properties, and bioimaging of living cells of bis-β-diketonate phenothiazine ligands and its cyclic dinuclear complexes.

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Tytuł:: Synthesis, crystal structures, photophysical properties, and bioimaging of living cells of bis-β-diketonate phenothiazine ligands and its cyclic dinuclear complexes.
Autorzy:: Li D; Department of Chemistry, Key Laboratory of Functional Inorganic Materials of Chemistry of Anhui Province, Anhui University, Hefei 230039, P.R. China.
Tian X
Hu G
Zhang Q
Wang P
Sun P
Zhou H
Meng X
Yang J
Wu J
Jin B
Zhang S
Tao X
Tian Y
Źródło:: Inorganic chemistry [Inorg Chem] 2011 Sep 05; Vol. 50 (17), pp. 7997-8006. Date of Electronic Publication: 2011 Aug 09.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Original Publication: [Easton, Pa.] American Chemical Society.
MeSH Terms:: Antineoplastic Agents/*pharmacology
Fluorescent Dyes/*pharmacology
Ketones/*chemistry
Metals, Heavy/*chemistry
Organometallic Compounds/*pharmacology
Phenothiazines/*chemistry
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Survival/drug effects ; Chemistry Techniques, Synthetic ; Crystallography, X-Ray ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Fluorescent Dyes/chemical synthesis ; Fluorescent Dyes/chemistry ; HeLa Cells ; Humans ; Ligands ; Models, Molecular ; Molecular Conformation ; Organometallic Compounds/chemical synthesis ; Organometallic Compounds/chemistry ; Photochemical Processes ; Quantum Theory ; Stereoisomerism ; Structure-Activity Relationship ; Tumor Cells, Cultured
Substance Nomenclature:: 0 (Antineoplastic Agents)
0 (Fluorescent Dyes)
0 (Ketones)
0 (Ligands)
0 (Metals, Heavy)
0 (Organometallic Compounds)
0 (Phenothiazines)
Entry Date(s):: Date Created: 20110811 Date Completed: 20111228 Latest Revision: 20110829
Update Code:: 20240104
DOI:: 10.1021/ic200150h
PMID:: 21827147
: Czasopismo naukowe

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Two bis-β-diketones, RCOCH(2)CO-EPTZ-COCH(2)COR (EPTZ = 10-ethylphenothiazine; R = C(6)H(5) for H(2)L(1) and CF(3) for H(2)L(2)) and their cyclic dinuclear Zn(II), Cd(II), Ni(II), Mn(II), Cu(II), Co(II) complexes have been synthesized and fully characterized. Their crystal structures were determined by single crystal X-ray diffraction analysis. Their photophysical properties have been further investigated both experimentally and theoretically. The results revealed that significant enhancement of two-photon absorption cross section values were obtained for the cyclic dinuclear Zn(II) and Cd(II) complexes compared with their free ligands. Additionally, confocal microscopy and two-photon microscopy fluorescent imaging of MCF-7 cells labeled with two ligands and Zn(II) complexes reveal their potential applications as a biological fluorescent probe.

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