A clinical commentary on the article "N-acetylglucosamine conjugated to nanoparticles enhances myocyte uptake and improves delivery of a small molecule p38 inhibitor for post-infarct healing" : N-acetylglucosamine conjugated nanoparticles: translational opportunities and barriers.

Tytuł:: A clinical commentary on the article "N-acetylglucosamine conjugated to nanoparticles enhances myocyte uptake and improves delivery of a small molecule p38 inhibitor for post-infarct healing" : N-acetylglucosamine conjugated nanoparticles: translational opportunities and barriers.
Autorzy:: Levit RD
Taylor WR
Źródło:: Journal of cardiovascular translational research [J Cardiovasc Transl Res] 2011 Oct; Vol. 4 (5), pp. 644-5. Date of Electronic Publication: 2011 Aug 18.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Original Publication: New York, NY : Springer
MeSH Terms:: Drug Carriers*
Nanoparticles*
Acetylglucosamine/*chemistry
Cardiovascular Agents/*administration & dosage
Imidazoles/*administration & dosage
Myocardial Infarction/*drug therapy
Myocardium/*enzymology
Polymers/*chemistry
Protein Kinase Inhibitors/*administration & dosage
Pyrimidines/*administration & dosage
p38 Mitogen-Activated Protein Kinases/*antagonists & inhibitors
Animals ; Cardiovascular Agents/chemistry ; Cardiovascular Agents/metabolism ; Chemistry, Pharmaceutical ; Disease Models, Animal ; Drug Compounding ; Imidazoles/chemistry ; Imidazoles/metabolism ; Myocardial Infarction/enzymology ; Myocardial Infarction/pathology ; Myocardial Infarction/physiopathology ; Myocardium/pathology ; Protein Kinase Inhibitors/chemistry ; Protein Kinase Inhibitors/metabolism ; Pyrimidines/chemistry ; Pyrimidines/metabolism ; Regeneration/drug effects ; p38 Mitogen-Activated Protein Kinases/metabolism
References:: J Control Release. 2007 Sep 26;122(2):189-98. (PMID: 17681632)
Proteomics. 2008 Aug;8(16):3294-302. (PMID: 18646010)
Substance Nomenclature:: 0 (Cardiovascular Agents)
0 (Drug Carriers)
0 (Imidazoles)
0 (Polymers)
0 (Protein Kinase Inhibitors)
0 (Pyrimidines)
0 (poly(cyclohexane-1,4-diyl acetone dimethylene ketal))
EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases)
HII3DC8CPI (SB 239063)
V956696549 (Acetylglucosamine)
Entry Date(s):: Date Created: 20110819 Date Completed: 20120112 Latest Revision: 20211020
Update Code:: 20240104
DOI:: 10.1007/s12265-011-9305-z
PMID:: 21850557
: Czasopismo naukowe

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Targeting drugs and nanoparticles to cardiomyocytes has been an elusive challenge. Cardiomyocytes are inherently non-phagocytic and their environment is subjected to contractile forces which tend to expel injected and catheter-delivered drugs. In this issue, a novel-targeting strategy, N-acetyl-glucosamine (GlcNAc) coating, is shown to enhance cardiomyocyte nanoparticle uptake both in vitro and in vivo. Many effective and proven therapies for myocardial infarction are in clinical use thus raising the bar for the translation of new technologies. Nevertheless, GlcNAc targeting represents a promising approach for improved targeting of drug therapies to cardiomyocytes.

Comment in: J Cardiovasc Transl Res. 2011 Oct;4(5):631-43. (PMID: 21833815)

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