Gankyrin, a biomarker for epithelial carcinogenesis, is overexpressed in human oral cancer.

Szczegóły
Abstrakt

Tytuł:: Gankyrin, a biomarker for epithelial carcinogenesis, is overexpressed in human oral cancer.
Autorzy:: Li J; Division of Environmental Health Sciences, College of Public Health, The Ohio State University, Columbus, OH 43210, USA. />Knobloch TJ
Kresty LA
Zhang Z
Lang JC
Schuller DE
Weghorst CM
Źródło:: Anticancer research [Anticancer Res] 2011 Sep; Vol. 31 (9), pp. 2683-92.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
Język:: English
Imprint Name(s):: Publication: Attiki, Greece : International Institute of Anticancer Research
Original Publication: Athens, Greece : Potamitis Press
MeSH Terms:: Cell Transformation, Neoplastic*
Biomarkers, Tumor/*metabolism
Carcinoma, Squamous Cell/*metabolism
Mouth Neoplasms/*metabolism
Proteasome Endopeptidase Complex/*metabolism
Proto-Oncogene Proteins/*metabolism
Adult ; Aged ; Base Sequence ; Carcinoma, Squamous Cell/pathology ; DNA Primers ; Female ; Humans ; Male ; Middle Aged ; Mouth Neoplasms/pathology ; Proteasome Endopeptidase Complex/genetics ; Proto-Oncogene Proteins/genetics ; Reverse Transcriptase Polymerase Chain Reaction
Grant Information:: R01 CA127368 United States CA NCI NIH HHS; R21 DE016361 United States DE NIDCR NIH HHS; R01 DE011943 United States DE NIDCR NIH HHS; R01 CA69472 United States CA NCI NIH HHS
Substance Nomenclature:: 0 (Biomarkers, Tumor)
0 (DNA Primers)
0 (PSMD10 protein, human)
0 (Proto-Oncogene Proteins)
EC 3.4.25.1 (Proteasome Endopeptidase Complex)
Entry Date(s):: Date Created: 20110827 Date Completed: 20111018 Latest Revision: 20211020
Update Code:: 20240104
PMID:: 21868508
: Czasopismo naukowe

Unlabelled: Little is known about the potential involvement of the oncoprotein gankyrin in human oral cancer progression. In this study, the levels of gankyrin mRNA and protein expression were assessed in human oral epithelial cell lines, at-risk normal oral tissues, premalignant oral lesions, and primary oral squamous cell carcinomas (OSCCs).
Materials and Methods: Biopsies included 6 oral epithelial cell lines, 32 OSCC specimens for qRT-PCR analysis, 27 OSCC specimens and 12 premalignant oral lesions for immunohistochemical analysis.
Results: Gankyrin was overexpressed in all tested oral epithelial cell lines and the majority of OSCC specimens (32/32 (100%) and 21/27 (71%) at the mRNA and protein levels, respectively). Moreover, 6/12 of premalignant oral lesions overexpressed gankyrin protein.
Conclusion: Gankyrin overexpression is a prevalent event in human oral cancer and occurs during the early stages of oral carcinogenesis, thus being a viable therapeutic or chemopreventive target in oral cancer.

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