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Tytuł:
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Developmental variations of plasma gamma-glutamyltransferase fractions in humans and in laboratory mammalians.
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Autorzy:
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Fierabracci V; Department of Experimental Pathology, University of Pisa, Italy.
Franzini M
Baggiani A
Fornaciari I
Burchielli S
Urciuoli P
Lamanna R
Lapi S
Nocchi F
Iorio MC
Emdin M
Pompella A
Paolicchi A
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Źródło:
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Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals [Biomarkers] 2012 Feb; Vol. 17 (1), pp. 43-7. Date of Electronic Publication: 2011 Dec 23.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: 2015- : Abingdon, Oxford : Tayor & Francis
Original Publication: London : Taylor & Francis, c1996-
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MeSH Terms:
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Fetal Blood/*enzymology
Liver/*enzymology
Liver/*growth & development
gamma-Glutamyltransferase/*blood
Adult ; Age Factors ; Animals ; Animals, Newborn ; Biomarkers/blood ; Chromatography, Gel/methods ; Female ; Humans ; Infant, Newborn ; Mice ; Rabbits ; Rats ; Sheep ; Swine ; gamma-Glutamyltransferase/isolation & purification
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Substance Nomenclature:
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0 (Biomarkers)
EC 2.3.2.2 (gamma-Glutamyltransferase)
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Entry Date(s):
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Date Created: 20111224 Date Completed: 20120525 Latest Revision: 20151119
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Update Code:
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20240104
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DOI:
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10.3109/1354750X.2011.635807
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PMID:
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22191706
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Plasma samples from human cord blood, and fetuses, newborns, and adults of different mammalians species were analyzed by gel-filtration chromatography, to ascertain whether gamma-glutamyltransferase (GGT) fractions reflect liver maturation. Human cord blood plasma showed higher b-, m-, and s-GGT fraction as compared to adult women. In rat and mouse fetuses and in newborns, b-GGT was the most abundant fraction. As in adult humans, in adult rats, mice, rabbits, sheep, and mini pigs, f-GGT was the most abundant fraction. GGT fractions are a common feature of all mammalian species tested. Their pattern changes seem to reflect liver postnatal maturation, function.
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