A sensitive capillary GC-MS method for analysis of topiramate from plasma obtained from single-dose studies.

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Tytuł:: A sensitive capillary GC-MS method for analysis of topiramate from plasma obtained from single-dose studies.
Autorzy:: Conway JM; Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN, USA.
Birnbaum AK
Marino SE
Cloyd JC
Remmel RP
Źródło:: Biomedical chromatography : BMC [Biomed Chromatogr] 2012 Sep; Vol. 26 (9), pp. 1071-6. Date of Electronic Publication: 2012 Jan 04.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Publication: 1990- : Chichester : Wiley
Original Publication: London : Heyden & Son, c1986-1990
MeSH Terms:: Fructose/*analogs & derivatives
Gas Chromatography-Mass Spectrometry/*methods
Dibenzocycloheptenes/blood ; Fructose/blood ; Fructose/isolation & purification ; Fructose/pharmacokinetics ; Humans ; Reproducibility of Results ; Sensitivity and Specificity ; Solid Phase Extraction ; Topiramate
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Grant Information:: K01 NS050309 United States NS NINDS NIH HHS; P50 NS016308 United States NS NINDS NIH HHS; P50-NS16308 United States NS NINDS NIH HHS
Substance Nomenclature:: 0 (Dibenzocycloheptenes)
0H73WJJ391 (Topiramate)
30237-26-4 (Fructose)
6R22P8K61P (cyheptamide)
Entry Date(s):: Date Created: 20120107 Date Completed: 20130220 Latest Revision: 20211021
Update Code:: 20240104
PubMed Central ID:: PMC3776594
DOI:: 10.1002/bmc.1749
PMID:: 22223467
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Topiramate (Topamax®) is an antiepileptic medication used as adjunctive and monotherapy in patients with epilepsy and for migraine prophylaxis. A GC-MS assay was developed that was capable of detecting topiramate plasma concentrations following a single rectal or oral dose administration. Topiramate plasma samples were prepared by solid-phase extraction and were quantified by GC-MS analysis. The topiramate standard curves were split from 0.1 to 4 µg/mL and from 4 to 40 µg/mL in order to give a more accurate determination of the topiramate concentration. The accuracy of the standards ranged from 94.6 to 107.3% and the precision (%CV) ranged from 1.0 to 5.3% for both curves at all concentrations. The %CV for quality controls was <7.6%. The assay is both accurate and precise and will be used to complete future pharmacokinetic studies.
(Copyright © 2012 John Wiley & Sons, Ltd.)

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