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Tytuł pozycji:

Metabolomic profiling of fatty acid and amino acid metabolism in youth with obesity and type 2 diabetes: evidence for enhanced mitochondrial oxidation.

Tytuł :
Metabolomic profiling of fatty acid and amino acid metabolism in youth with obesity and type 2 diabetes: evidence for enhanced mitochondrial oxidation.
Autorzy :
Mihalik SJ; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Michaliszyn SF
de las Heras J
Bacha F
Lee S
Chace DH
DeJesus VR
Vockley J
Arslanian SA
Pokaż więcej
Źródło :
Diabetes care [Diabetes Care] 2012 Mar; Vol. 35 (3), pp. 605-11. Date of Electronic Publication: 2012 Jan 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Język :
English
Imprint Name(s) :
Publication: Alexandria Va : American Diabetes Association
Original Publication: New York, American Diabetes Assn.
MeSH Terms :
Amino Acids/*metabolism
Diabetes Mellitus, Type 2/*embryology
Fatty Acids/*metabolism
Obesity/*embryology
Absorptiometry, Photon ; Adolescent ; Carnitine/analogs & derivatives ; Carnitine/metabolism ; Fasting ; Female ; Humans ; Male
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Grant Information :
UL1 RR024153 United States RR NCRR NIH HHS; K24 HD001357 United States HD NICHD NIH HHS; M01_RR-00084 United States RR NCRR NIH HHS; K24 HD-01357 United States HD NICHD NIH HHS; R01 HD-27503 United States HD NICHD NIH HHS; R01 DK078775 United States DK NIDDK NIH HHS; R0I DK-78775 United States DK NIDDK NIH HHS; R01 HD027503 United States HD NICHD NIH HHS
Substance Nomenclature :
0 (Amino Acids)
0 (Fatty Acids)
0 (acylcarnitine)
S7UI8SM58A (Carnitine)
Entry Date(s) :
Date Created: 20120124 Date Completed: 20120626 Latest Revision: 20211021
Update Code :
20211022
PubMed Central ID :
PMC3322714
DOI :
10.2337/DC11-1577
PMID :
22266733
Czasopismo naukowe
Objective: We compared acylcarnitine (AcylCN) species, common amino acid and fat oxidation (FOX) byproducts, and plasma amino acids in normal weight (NW; n = 39), obese (OB; n = 64), and type 2 diabetic (n = 17) adolescents.
Research Design and Methods: Fasting plasma was analyzed by tandem mass spectrometry, body composition by dual energy X-ray absorptiometry and computed tomography, and total-body lipolysis and substrate oxidation by [(2)H(5)]glycerol and indirect calorimetry, respectively. In vivo insulin sensitivity (IS) was assessed with a 3-h hyperinsulinemic-euglycemic clamp.
Results: Long-chain AcylCNs (C18:2-CN to C14:0-CN) were similar among the three groups. Medium- to short-chain AcylCNs (except C8 and C10) were significantly lower in type 2 diabetes compared with NW, and when compared with OB, C2-, C6-, and C10-CN were lower. Amino acid concentrations were lower in type 2 diabetes compared with NW. Fasting lipolysis and FOX were higher in OB and type 2 diabetes compared with NW, and the negative association of FOX to C10:1 disappeared after controlling for adiposity, Tanner stage, and sex. IS was lower in OB and type 2 diabetes with positive associations between IS and arginine, histidine, and serine after adjusting for adiposity, Tanner stage, and sex.
Conclusions: These metabolomics results, together with the increased rates of in vivo FOX, are not supportive of defective fatty acid or amino acid metabolism in obesity and type 2 diabetes in youth. Such observations are consistent with early adaptive metabolic plasticity in youth, which over time-with continued obesity and aging-may become dysfunctional, as observed in adults.

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