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Tytuł pozycji:

Early formative stage of human focal cortical gyration anomalies: fetal MRI.

Tytuł:
Early formative stage of human focal cortical gyration anomalies: fetal MRI.
Autorzy:
Righini A; Department of Radiology and Neuroradiology, Children's Hospital V. Buzzi, Via Castelvetro 32, Milan 20154, Italy. />Parazzini C
Doneda C
Avagliano L
Arrigoni F
Rustico M
Consonni D
Re TJ
Bulfamante G
Triulzi F
Źródło:
AJR. American journal of roentgenology [AJR Am J Roentgenol] 2012 Feb; Vol. 198 (2), pp. 439-47.
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Publication: <2004-> : Leesburg, VA : American Roentgen Ray Society
Original Publication: Springfield, Ill., Thomas.
MeSH Terms:
Brain/*abnormalities
Magnetic Resonance Imaging/*methods
Malformations of Cortical Development/*diagnosis
Prenatal Diagnosis/*methods
Diagnosis, Differential ; Female ; Humans ; Male ; Pregnancy ; Retrospective Studies
Entry Date(s):
Date Created: 20120124 Date Completed: 20120403 Latest Revision: 20120123
Update Code:
20240104
DOI:
10.2214/AJR.11.6662
PMID:
22268191
Czasopismo naukowe
Objective: Limited information is available about the development of focal cortical gyration anomalies in the human brain. Using prenatal MRI, we characterized focal cortical gyration anomalies at an early formative stage and sought clues about the mechanisms of their development.
Materials and Methods: From a large prenatal MRI database, 30 cases (gestational age, ≤ 24 weeks) with reported focal distortion of the cortical rim profile were selected. Eight cases were matched with histologic examinations; another seven had prenatal MRI, MRI autopsy, or postnatal MRI follow-up; and 15 had no follow-up but did present analogous abnormal cortical features. Focal cortical gyration anomalies were detectable when the brain was still smooth (i.e., physiological lissencephaly).
Results: Four patterns of cortical plate anomaly were identified: wartlike (11 cases), abnormal invaginating sulcus (11 cases), sawtooth (six cases), and single or multiple bumps (two cases). A thinned or blurred subplate and intermediate zone in the focal cortical gyration anomaly site was detected in 80% of cases. All but two cases had other intracranial anomalies. Seven cases were classified as hypoxic-ischemic, five as genetic, and three as infective. In 15 cases, the cause could not be established. In five fetuses with further intrauterine or postnatal MRI, focal cortical gyration anomalies increased in complexity, fulfilling postnatal imaging criteria of polymicrogyria.
Conclusion: Focal cortical gyration anomalies can be detected at the early sulcation process stage. The process leading to abnormal gyration may evolve faster than physiologic ones and seems to be related to alterations of parenchymal layering occurring before 24 weeks' gestation. Most focal cortical gyration anomalies evolve toward what is currently considered polymicrogyria.

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