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Tytuł pozycji:

[The effect of progesterone on metabolism of cholesterol esters in macrophages cultured with acetylated low density lipoproteins].

Tytuł:
[The effect of progesterone on metabolism of cholesterol esters in macrophages cultured with acetylated low density lipoproteins].
Autorzy:
Dolgov AV
Dushkin MI
Mandrikova EV
Transliterated Title:
Vliianie progesterona na metabolizm éfirov kholesterina v makrofagakh,kul'tiviruemykh s atsetilirovannymi lipoproteidami nizkoĭ plotnosti.
Źródło:
Voprosy meditsinskoi khimii [Vopr Med Khim] 1990 Jul-Aug; Vol. 36 (4), pp. 38-41.
Typ publikacji:
English Abstract; Journal Article
Język:
Russian
Imprint Name(s):
Publication: Moskva : Rossiĭskai︠a︡ Akademii︠a︡ Medit︠s︡inskikh Nauk
Original Publication: Moskva.
MeSH Terms:
Cholesterol Esters/*metabolism
Foam Cells/*metabolism
Lipoproteins, LDL/*metabolism
Progesterone/*pharmacology
Acetylation ; Cells, Cultured ; Cholesterol/metabolism ; Humans ; Lipoproteins, HDL/metabolism
Substance Nomenclature:
0 (Cholesterol Esters)
0 (Lipoproteins, HDL)
0 (Lipoproteins, LDL)
4G7DS2Q64Y (Progesterone)
97C5T2UQ7J (Cholesterol)
Entry Date(s):
Date Created: 19900701 Date Completed: 19901210 Latest Revision: 20131121
Update Code:
20240104
PMID:
2238531
Czasopismo naukowe
Effect of progesterone on esterification of free cholesterol, on content of free cholesterol and its esters was studied in rat macrophages, cultivated in presence of acetyl-derivatives of low density lipoproteins (Ac-LDL), as well as on mobilization of cholesterol from macrophages. Progesterone at a dose of 0.5-10 micrograms per I ml of cultivating medium caused dose-dependent inhibition of I-14C-oleate incorporation into cholesterol esters of macrophages cultivated with Ac-LDL (50 micrograms of protein/ml). In the medium free of LDL progesterone caused an increase of cholesterol in macrophages by 45%, while addition of 100 micrograms/ml LDL led to a decrease of free cholesterol by 20% of the initial level. If macrophages pre-enriched with 4-C14-cholesterol were cultivated in LDL containing medium, progesterone increased the 4-14C-cholesterol liberation into medium and decreased the cholesterol content in macrophages. Under conditions of macrophages incubation in the LDL-free medium, progesterone increased the free cholesterol content in these cells but did not affect the 4-14C-cholesterol liberation into medium. The data obtained suggest that the progesterone-induced inhibition of free cholesterol esterification may increase its mobilization from macrophages only if the LDL acceptor function is unaltered.

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