Hematopoietic Stem Cell Mobilization and Homing after Transplantation: The Role of MMP-2, MMP-9, and MT1-MMP.

Szczegóły
Abstrakt

Tytuł:: Hematopoietic Stem Cell Mobilization and Homing after Transplantation: The Role of MMP-2, MMP-9, and MT1-MMP.
Autorzy:: Shirvaikar N; Research & Development, Canadian Blood Services, 8249 114th Street NW, Edmonton, AB, Canada T6G 2R8.
Marquez-Curtis LA
Janowska-Wieczorek A
Źródło:: Biochemistry research international [Biochem Res Int] 2012; Vol. 2012, pp. 685267. Date of Electronic Publication: 2012 Mar 04.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Original Publication: New York, NY : Hindawi Pub. Corp.
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Entry Date(s):: Date Created: 20120413 Date Completed: 20120823 Latest Revision: 20230502
Update Code:: 20240104
PubMed Central ID:: PMC3310200
DOI:: 10.1155/2012/685267
PMID:: 22496978
: Czasopismo naukowe

Pełny tekst

Hematopoietic stem/progenitor cells (HSPCs) are used in clinical transplantation to restore hematopoietic function. Here we review the role of the soluble matrix metalloproteinases MMP-2 and MMP-9, and membrane type (MT)1-MMP in modulating processes critical to successful transplantation of HSPC, such as mobilization and homing. Growth factors and cytokines which are employed as mobilizing agents upregulate MMP-2 and MMP-9. Recently we demonstrated that MT1-MMP enhances HSPC migration across reconstituted basement membrane, activates proMMP-2, and contributes to a highly proteolytic bone marrow microenvironment that facilitates egress of HSPC. On the other hand, we reported that molecules secreted during HSPC mobilization and collection, such as hyaluronic acid and thrombin, increase MT1-MMP expression in cord blood HSPC and enhance (prime) their homing-related responses. We suggest that modulation of MMP-2, MMP-9, and MT1-MMP expression has potential for development of new therapies for more efficient mobilization, homing, and engraftment of HSPC, which could lead to improved transplantation outcomes.

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