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Tytuł:
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Primary chemoradiotherapy for oral cavity squamous cell carcinoma.
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Autorzy:
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Crombie AK; Maxillofacial Unit, Royal Brisbane & Women's Hospital, Butterfield Street, Herston, Qld 4029, Australia; The University of Queensland, School of Dentistry, Brisbane, Qld 4000, Australia; The University of Queensland, Centre for Clinical Research, Herston, Qld 4029, Australia. Electronic address: .
Farah C; The University of Queensland, School of Dentistry, Brisbane, Qld 4000, Australia; The University of Queensland, Centre for Clinical Research, Herston, Qld 4029, Australia.
Tripcony L; Department of Radiation Oncology, Cancer Care Services, Royal Brisbane & Women's Hospital, Butterfield Street, Herston, Qld 4029, Australia.
Dickie G; Department of Radiation Oncology, Cancer Care Services, Royal Brisbane & Women's Hospital, Butterfield Street, Herston, Qld 4029, Australia.
Batstone MD; Maxillofacial Unit, Royal Brisbane & Women's Hospital, Butterfield Street, Herston, Qld 4029, Australia; The University of Queensland, School of Dentistry, Brisbane, Qld 4000, Australia.
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Źródło:
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Oral oncology [Oral Oncol] 2012 Oct; Vol. 48 (10), pp. 1014-1018. Date of Electronic Publication: 2012 Apr 18.
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Typ publikacji:
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Comparative Study; Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: Amsterdam : Elsevier
Original Publication: Oxford ; New York : Pergamon, c1997-
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MeSH Terms:
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Carcinoma, Squamous Cell/*therapy
Chemoradiotherapy/*adverse effects
Mouth Neoplasms/*therapy
Osteoradionecrosis/*etiology
Radiotherapy/*adverse effects
Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Survival Analysis ; Treatment Outcome
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Entry Date(s):
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Date Created: 20120421 Date Completed: 20130529 Latest Revision: 20180217
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Update Code:
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20240104
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DOI:
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10.1016/j.oraloncology.2012.03.027
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PMID:
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22516377
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Objectives: To evaluate the survival of patients with oral cavity squamous cell carcinoma (SCC) treated with chemoradiotherapy (CRT) or radiotherapy (RT). To record the rate of osteoradionecrosis (ORN) and need for alternative feeding of patients with oral cavity cancer treated with CRT or RT.
Materials and Methods: All patients with first presentation of oral cavity SCC treated with CRT or RT only at the Royal Brisbane & Women's Hospital (RBWH) between 2000 and 2007 were included. Patient Demographics (age, sex), ACE-27 Co-morbidity index, Staging (TNM staging system), Type of Chemotherapy and Dose of RT, Overall Survival (OS) and Disease-Specific Survival (DSS), Attempt at Salvage, development of distant metastases, development of ORN and success of treatment for ORN and requirement for alternative feeding (PEG/NGT) were recorded.
Results: Fifty-four patients met the inclusion criteria. One patient died due to toxicity of treatment. The 5-year OS was 29%. The 5-year DSS was 30%. The rate of ORN amongst survivors was 36%.
Conclusions: CRT is successful in a small number of patients with oral cavity SCC. When compared to the published literature, surgery with or without post-operative RT has better survival rates. Salvage surgery does not appear to be a viable option for management of recurrence post CRT. The consequences of treatment, namely ORN and need for alternative feeding, are high.
(Crown Copyright © 2012. Published by Elsevier Ltd. All rights reserved.)
