Comparative risk of liver-related mortality from chronic hepatitis B versus chronic hepatitis C virus infection.

Szczegóły
Abstrakt

Tytuł:: Comparative risk of liver-related mortality from chronic hepatitis B versus chronic hepatitis C virus infection.
Autorzy:: Falade-Nwulia O; Division of Infectious Diseases, Johns Hopkins University, Baltimore, 21287, USA. />Seaberg EC
Rinaldo CR
Badri S
Witt M
Thio CL
Źródło:: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2012 Aug; Vol. 55 (4), pp. 507-13. Date of Electronic Publication: 2012 Apr 20.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
Język:: English
Imprint Name(s):: Publication: Jan. 2011- : Oxford : Oxford University Press
Original Publication: Chicago, IL : The University of Chicago Press, c1992-
MeSH Terms:: Hepatitis B, Chronic/*mortality
Hepatitis B, Chronic/*virology
Hepatitis C, Chronic/*mortality
Hepatitis C, Chronic/*virology
Adult ; HIV Infections/epidemiology ; HIV Infections/virology ; HIV-1/isolation & purification ; Humans ; Male ; Middle Aged ; Poisson Distribution ; Prospective Studies ; United States/epidemiology
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Grant Information:: U01 AI035042 United States AI NIAID NIH HHS; UL1 RR025005 United States RR NCRR NIH HHS; UO1-AI-35042 United States AI NIAID NIH HHS; UO1-AI-35040 United States AI NIAID NIH HHS; UO1-AI-35041 United States AI NIAID NIH HHS; U01 AI035041 United States AI NIAID NIH HHS; UL1-RR025005 United States RR NCRR NIH HHS; U01 AI035043 United States AI NIAID NIH HHS; UO1-AI-35039 United States AI NIAID NIH HHS; U01 AI035040 United States AI NIAID NIH HHS; U01 AI035039 United States AI NIAID NIH HHS; UO1-AI-35043 United States AI NIAID NIH HHS
Entry Date(s):: Date Created: 20120424 Date Completed: 20130211 Latest Revision: 20220318
Update Code:: 20240104
PubMed Central ID:: PMC3520384
DOI:: 10.1093/cid/cis432
PMID:: 22523269
: Czasopismo naukowe

Background: It is not known whether chronic hepatitis B (CH-B) or chronic hepatitis C (CH-C) carries a greater risk of liver-related mortality. This study compared rates of liver-related mortality between these 2 groups in the Multicenter AIDS Cohort Study (MACS).
Methods: Six hundred eighty men with CH-B (n = 337) or CH-C (n = 343) at study entry into the MACS were prospectively followed to death, last follow-up visit, or 30 March 2010, whichever came first. Four hundred seventy-two (69.4%) of these men were infected with human immunodeficiency virus type 1 (HIV-1). Causes of death were obtained from death registry matching and death certificates. Liver-related and all-cause mortality rates (MRs) were compared between groups using Poisson regression and adjusted for potential confounders and competing risks.
Results: In 6728 person-years (PYs) of follow-up, there were 293 deaths from all causes (43.5 per 1000 PYs), of which 51 were liver-related (7.6 per 1000 PYs). The all-cause MR was similar between those with CH-B and CH-C; however, the liver-related MR was significantly higher in those with CH-B (9.6 per 1000 PYs; 95% confidence interval [CI], 6.9-13.2) than those with CH-C (5.0 per 1000 PYs; 95% CI, 3.0-8.4). In the HIV-infected subgroup, which had 46 (90.2%) of the liver-related deaths, the liver-related MR remained higher from CH-B after adjusting for potential confounders (incidence rate ratio, 2.2; P = .03) and competing risks (subhazard rate ratio, 2.4; P = .02). Furthermore, among HIV-infected subjects, CD4 cell counts <200 cells/mm(3) were associated with a 16.2-fold (95% CI, 6.1-42.8) increased risk of liver-related death compared with CD4 cell counts >350 cell/mm(3).
Conclusions: Chronic hepatitis B carries a higher risk of death from liver disease than does CH-C, especially in HIV-infected men with greater immunosuppression.

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