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Tytuł pozycji:

HEMD: an integrated tool of human epigenetic enzymes and chemical modulators for therapeutics.

Tytuł :
HEMD: an integrated tool of human epigenetic enzymes and chemical modulators for therapeutics.
Autorzy :
Huang Z; Department of Pathophysiology and Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, School of Medicine, Shanghai Jiao-Tong University, Shanghai, China.
Jiang H
Liu X
Chen Y
Wong J
Wang Q
Huang W
Shi T
Zhang J
Pokaż więcej
Źródło :
PloS one [PLoS One] 2012; Vol. 7 (6), pp. e39917. Date of Electronic Publication: 2012 Jun 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Język :
English
Imprint Name(s) :
Original Publication: San Francisco, CA : Public Library of Science
MeSH Terms :
Epigenesis, Genetic*
Enzymes/*pharmacology
Databases, Factual ; Enzymes/drug effects ; Humans ; Internet ; User-Computer Interface
References :
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Substance Nomenclature :
0 (Enzymes)
Entry Date(s) :
Date Created: 20120705 Date Completed: 20130104 Latest Revision: 20181113
Update Code :
20210209
PubMed Central ID :
PMC3382562
DOI :
10.1371/journal.pone.0039917
PMID :
22761927
Czasopismo naukowe
Background: Epigenetic mechanisms mainly include DNA methylation, post-translational modifications of histones, chromatin remodeling and non-coding RNAs. All of these processes are mediated and controlled by enzymes. Abnormalities of the enzymes are involved in a variety of complex human diseases. Recently, potent natural or synthetic chemicals are utilized to establish the quantitative contributions of epigenetic regulation through the enzymes and provide novel insight for developing new therapeutics. However, the development of more specific and effective epigenetic therapeutics requires a more complete understanding of the chemical epigenomic landscape.
Description: Here, we present a human epigenetic enzyme and modulator database (HEMD), the database which provides a central resource for the display, search, and analysis of the structure, function, and related annotation for human epigenetic enzymes and chemical modulators focused on epigenetic therapeutics. Currently, HEMD contains 269 epigenetic enzymes and 4377 modulators in three categories (activators, inhibitors, and regulators). Enzymes are annotated with detailed description of epigenetic mechanisms, catalytic processes, and related diseases, and chemical modulators with binding sites, pharmacological effect, and therapeutic uses. Integrating the information of epigenetic enzymes in HEMD should allow for the prediction of conserved features for proteins and could potentially classify them as ideal targets for experimental validation. In addition, modulators curated in HEMD can be used to investigate potent epigenetic targets for the query compound and also help chemists to implement structural modifications for the design of novel epigenetic drugs.
Conclusions: HEMD could be a platform and a starting point for biologists and medicinal chemists for furthering research on epigenetic therapeutics. HEMD is freely available at http://mdl.shsmu.edu.cn/HEMD/.

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