The interaction of carbon dioxide and hypoxia in the control of cerebral blood flow.

Tytuł:: The interaction of carbon dioxide and hypoxia in the control of cerebral blood flow.
Autorzy:: Mardimae A; Department of Physiology, University of Toronto, Toronto, ON, Canada, M5S 1A8.
Balaban DY
Machina MA
Battisti-Charbonney A
Han JS
Katznelson R
Minkovich LL
Fedorko L
Murphy PM
Wasowicz M
Naughton F
Meineri M
Fisher JA
Duffin J
Źródło:: Pflugers Archiv : European journal of physiology [Pflugers Arch] 2012 Oct; Vol. 464 (4), pp. 345-51. Date of Electronic Publication: 2012 Sep 09.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Original Publication: Berlin, New York, Springer.
MeSH Terms:: Carbon Dioxide/*physiology
Cerebrovascular Circulation/*physiology
Hypoxia/*physiopathology
Adult ; Blood Flow Velocity/physiology ; Blood Gas Analysis ; Carbon Dioxide/blood ; Female ; Humans ; Hypoxia/blood ; Inhalation ; Male ; Middle Aged ; Middle Cerebral Artery/physiology ; Oxygen/blood ; Oxygen/physiology ; Regional Blood Flow/physiology
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Substance Nomenclature:: 142M471B3J (Carbon Dioxide)
S88TT14065 (Oxygen)
Entry Date(s):: Date Created: 20120911 Date Completed: 20130110 Latest Revision: 20211021
Update Code:: 20240104
DOI:: 10.1007/s00424-012-1148-1
PMID:: 22961068
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Both hypoxia and carbon dioxide increase cerebral blood flow (CBF), and their effective interaction is currently thought to be additive. Our objective was to test this hypothesis. Eight healthy subjects breathed a series of progressively hypoxic gases at three levels of carbon dioxide. Middle cerebral artery velocity, as an index of CBF; partial pressures of carbon dioxide and oxygen and concentration of oxygen in arterial blood; and mean arterial blood pressure were monitored. The product of middle cerebral artery velocity and arterial concentration of oxygen was used as an index of cerebral oxygen delivery. Two-way repeated measures analyses of variance (rmANOVA) found a significant interaction of carbon dioxide and hypoxia factors for both CBF and cerebral oxygen delivery. Regression models using sigmoidal dependence on carbon dioxide and a rectangular hyperbolic dependence on hypoxia were fitted to the data to illustrate this interaction. We concluded that carbon dioxide and hypoxia act synergistically in their control of CBF so that the delivery of oxygen to the brain is enhanced during hypoxic hypercapnia and, although reduced during normoxic hypocapnia, can be restored to normal levels with progressive hypoxia.

Erratum in: Pflugers Arch. 2013 Feb;465(2):343. Battisti-Charbonney, Anne [added].

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