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Tytuł pozycji:

Effects of aqueous extract of Hibiscus sabdariffa on renal Na(+)-K(+)-ATPase and Ca(2+)-Mg(2+)-ATPase activities in Wistar rats.

Tytuł :
Effects of aqueous extract of Hibiscus sabdariffa on renal Na(+)-K(+)-ATPase and Ca(2+)-Mg(2+)-ATPase activities in Wistar rats.
Autorzy :
Olatunji LA; Department of Physiology, University of Ilorin, Ilorin, Nigeria. />Usman TO
Adebayo JO
Olatunji VA
Pokaż więcej
Źródło :
Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine [Zhong Xi Yi Jie He Xue Bao] 2012 Sep; Vol. 10 (9), pp. 1049-55.
Typ publikacji :
Journal Article
Język :
English
Imprint Name(s) :
Original Publication: Shanghai : "Zhong xi yi jie he xue bao" za zhi she
MeSH Terms :
Ca(2+) Mg(2+)-ATPase/*metabolism
Hibiscus/*chemistry
Kidney/*drug effects
Plant Extracts/*pharmacology
Sodium-Potassium-Exchanging ATPase/*metabolism
Adenosine Triphosphatases/drug effects ; Adenosine Triphosphatases/metabolism ; Animals ; Kidney/enzymology ; Male ; Rats ; Rats, Wistar
Substance Nomenclature :
0 (Plant Extracts)
EC 3.6.1.- (Adenosine Triphosphatases)
EC 3.6.1.- (Ca(2+) Mg(2+)-ATPase)
EC 7.2.2.13 (Sodium-Potassium-Exchanging ATPase)
Entry Date(s) :
Date Created: 20120918 Date Completed: 20130513 Latest Revision: 20191210
Update Code :
20210623
PMID :
22979937
Czasopismo naukowe
Objective: To investigate the effects of oral administration of aqueous extract of Hibiscus sabdariffa on renal Na(+)-K(+)-ATPase and Ca(2+)-Mg(2+)-ATPase activities in rats.
Methods: The 25 and 50 mg/(kg·d) of aqueous extracts of H. sabdariffa were respectively given to rats in the experimental groups for 28 d, and rats in the control group received an appropriate volume of distilled water as vehicle. Na(+)-K(+)-ATPase and Ca(2+)-Mg(2+)-ATPase activities in the kidney were assayed by spectrophotometric method.
Results: Administrations of 25 and 50 mg/(kg·d) of aqueous extract of H. sabdariffa significantly decreased the Ca(2+)-Mg(2+)-ATPase activity in the kidney of rats (P<0.05). However, the renal Na(+)-K(+)-ATPase activity of the experimental rats was not affected by either dose of the extract. And the plasma Na(+), K(+) and Ca(2+) levels of the experimental rats had no significant changes. Administration of either dose of the extract did not result in any significant changes in body and kidney weights, the concentrations of plasma albumin and total protein, and alkaline phosphatase, aspartate aminotransferase and alanine aminotransferase activities. However, concentrations of creatinine and urea were significantly reduced by 50 mg/kg of the extract (P<0.05).
Conclusion: The present study indicates that oral administration of aqueous extract of H. sabdariffa may preserve the renal function despite a decreased renal Ca(2+)-Mg(2+)-ATPase activity.

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