The analysis of the prevalence of mycoses based on the literature data and original observations gives evidence of the increase in the relative frequency of mycotic lesions in the overall ENT morbidity. The occurrence of otomycosis among otitides of different etiology is estimated at 25% and that of pharyngomycosis in the patients presenting with chronic pharygitis and tonsillitis up to 28%. The mycotic lesions in the larynx are diagnosed in almost 15% of the patients with chronic laryngitis. Chronic inflammation of intranasal cavity and paranasal sinuses is associated with mycosis in 7% of the patients. The factors that promote the development of mycotic lesions are considered and specific clinical manifestations described with special reference to their localization and taxonomical identification of the fungi. The optimal approaches to the diagnostics and treatment of ENT mycosis are discussed. The strategies of local and general antimycotic therapy are proposed with the use of modern antimycotic agents taking into account peculiarities of the clinical course of the disease, indications and contraindications for their application.