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Tytuł pozycji:

Monitoring time interval for pQCT-derived bone outcomes in postmenopausal women.

Tytuł :
Monitoring time interval for pQCT-derived bone outcomes in postmenopausal women.
Autorzy :
Duckham RL; College of Kinesiology, University of Saskatchewan, Saskatoon, SK, Canada.
Frank AW
Johnston JD
Olszynski WP
Kontulainen SA
Pokaż więcej
Źródło :
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA [Osteoporos Int] 2013 Jun; Vol. 24 (6), pp. 1917-22. Date of Electronic Publication: 2013 Jan 24.
Typ publikacji :
Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
Język :
English
Imprint Name(s) :
Original Publication: London, UK : Springer International, c1990-
MeSH Terms :
Bone Density/*physiology
Osteoporosis, Postmenopausal/*diagnostic imaging
Aged ; Aged, 80 and over ; Anthropometry/methods ; Female ; Follow-Up Studies ; Humans ; Middle Aged ; Monitoring, Physiologic/methods ; Osteoporosis, Postmenopausal/physiopathology ; Radius/diagnostic imaging ; Radius/physiopathology ; Tibia/diagnostic imaging ; Tibia/physiopathology ; Time Factors ; Tomography, X-Ray Computed/methods
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Grant Information :
Canada Canadian Institutes of Health Research
Entry Date(s) :
Date Created: 20130125 Date Completed: 20140121 Latest Revision: 20211021
Update Code :
20220301
DOI :
10.1007/s00198-012-2242-0
PMID :
23344257
Czasopismo naukowe
Unlabelled: Evidence of measurement precision, annual changes and monitoring time interval is essential when designing and interpreting longitudinal studies. Despite the precise measures, small annual changes in bone properties led to monitoring time intervals (MTIs) of 2-6 years in peripheral quantitative computed tomography (pQCT)-derived radial and tibial bone area, density, and estimated strength in postmenopausal women.
Introduction: The purpose of the study was to determine the precision error, annual change, and MTI in bone density, area, and strength parameters in postmenopausal women.
Methods: Postmenopausal women (n = 114) from the Saskatoon cohort of the Canadian Multicentre Osteoporosis Study had annual pQCT scans of the distal and shaft sites of the radius and tibia for 2 years. Median annualized rates of percent change and the MTI were calculated for bone density, area, and strength parameters. Root mean squared coefficients of variation (CV%) were calculated from duplicate scans in a random subgroup of 35 postmenopausal women.
Results: CV% ranged from 1.4 to 6.1 % at the radius and 0.7 to 2.1 % at the tibia. MTIs for the distal radius were 3 years for total bone density (ToD) and 4 years for total bone cross sectional area (ToA), trabecular area, and bone strength index. At the diaphyseal radius, MTI was 3 years for ToA, 5 years for cortical density, and 6 years for polar stress strain index (SSIp). Similarly, MTI for total and trabecular density was 3 years at the distal tibia. At the diaphyseal tibia, MTI for ToA was 3 years and SSIp 4 years.
Conclusion: MTI for longitudinal studies in older postmenopausal women should be at least 2-6 years at the radius and tibia, with specific monitoring of the total and trabecular area, total density, and bone strength at the radius and total and trabecular density, total area, and bone strength at the tibia.

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