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Tytuł pozycji:

A low-cost, reliable, high-throughput system for rodent behavioral phenotyping in a home cage environment.

Tytuł :
A low-cost, reliable, high-throughput system for rodent behavioral phenotyping in a home cage environment.
Autorzy :
Parkison SA; Department of Electrical Engineering, University of Nebraska-Lincoln, Lincoln, NE 68521, USA.
Carlson JD
Chaudoin TR
Hoke TA
Schenk AK
Goulding EH
Pérez LC
Bonasera SJ
Pokaż więcej
Źródło :
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference [Annu Int Conf IEEE Eng Med Biol Soc] 2012; Vol. 2012, pp. 2392-5.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Język :
English
Imprint Name(s) :
Original Publication: [Piscataway, NJ] : [IEEE], [2007]-
MeSH Terms :
Ecosystem*
Housing, Animal*
Actigraphy/*instrumentation
Behavior, Animal/*physiology
Monitoring, Ambulatory/*instrumentation
Photometry/*instrumentation
Signal Processing, Computer-Assisted/*instrumentation
Animals ; Equipment Design ; Equipment Failure Analysis ; Mice
References :
Annu Rev Genomics Hum Genet. 2008;9:49-69. (PMID: 18949851)
Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):1983-8. (PMID: 17261803)
Nat Neurosci. 2004 May;7(5):462-6. (PMID: 15114359)
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Exp Neurol. 2001 Aug;170(2):326-44. (PMID: 11476599)
Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20575-82. (PMID: 19106295)
Genes Brain Behav. 2006 Aug;5(6):458-66. (PMID: 16923150)
J Neurosci Methods. 2001 May 30;107(1-2):107-24. (PMID: 11389948)
Trends Neurosci. 2004 Jul;27(7):366-9. (PMID: 15219734)
NeuroRx. 2004 Jul;1(3):298-306. (PMID: 15717031)
Physiol Behav. 2001 Aug;73(5):731-44. (PMID: 11566207)
Drug Discov Today. 2002 Sep 15;7(18 Suppl):S107-12. (PMID: 12546875)
Science. 1999 Jun 4;284(5420):1670-2. (PMID: 10356397)
Behav Res Methods. 2008 May;40(2):613-21. (PMID: 18522073)
Nat Commun. 2010 Sep 07;1:68. (PMID: 20842193)
Mol Brain. 2008 Sep 15;1:7. (PMID: 18803809)
Grant Information :
R01 AG031158 United States AG NIA NIH HHS; AG031158 United States AG NIA NIH HHS
Entry Date(s) :
Date Created: 20130201 Date Completed: 20130801 Latest Revision: 20200928
Update Code :
20210623
PubMed Central ID :
PMC5061112
DOI :
10.1109/EMBC.2012.6346445
PMID :
23366406
Czasopismo naukowe
Inexpensive, high-throughput, low maintenance systems for precise temporal and spatial measurement of mouse home cage behavior (including movement, feeding, and drinking) are required to evaluate products from large scale pharmaceutical design and genetic lesion programs. These measurements are also required to interpret results from more focused behavioral assays. We describe the design and validation of a highly-scalable, reliable mouse home cage behavioral monitoring system modeled on a previously described, one-of-a-kind system. Mouse position was determined by solving static equilibrium equations describing the force and torques acting on the system strain gauges; feeding events were detected by a photobeam across the food hopper, and drinking events were detected by a capacitive lick sensor. Validation studies show excellent agreement between mouse position and drinking events measured by the system compared with video-based observation--a gold standard in neuroscience.

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