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Tytuł:
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Retrovirus infected cells contain viral microRNAs.
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Autorzy:
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Klase ZA; Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, 9000 Rockville Pike, Bethesda, MD 20810, USA.
Sampey GC
Kashanchi F
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Źródło:
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Retrovirology [Retrovirology] 2013 Feb 07; Vol. 10, pp. 15. Date of Electronic Publication: 2013 Feb 07.
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Typ publikacji:
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Editorial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Comment
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Język:
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English
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Imprint Name(s):
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Original Publication: [London] : BioMed Central, c2004-
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MeSH Terms:
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B-Lymphocytes/*metabolism
Leukemia Virus, Bovine/*genetics
MicroRNAs/*genetics
Neoplasms/*genetics
Animals ; Humans
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References:
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Grant Information:
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AI074410 United States AI NIAID NIH HHS; AI078859 United States AI NIAID NIH HHS
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Substance Nomenclature:
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0 (MicroRNAs)
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Entry Date(s):
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Date Created: 20130209 Date Completed: 20130729 Latest Revision: 20211021
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Update Code:
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20240104
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PubMed Central ID:
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PMC3571942
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DOI:
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10.1186/1742-4690-10-15
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PMID:
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23391025
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The encoding of microRNAs in retroviral genomes has remained a controversial hypothesis despite significant supporting evidence in recent years. A recent publication demonstrating the production of functional miRNAs from the retrovirus bovine leukemia virus adds further credence to the fact that retroviruses do indeed encode their own miRNAs. Here we comment on the importance of this paper to the field, as well as examine the other known examples of miRNAs encoded by RNA viruses.
Comment on: Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):3077-82. (PMID: 22308400)