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Tytuł:
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The impact of computed tomography on early glottic cancer outcomes.
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Autorzy:
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Mourad WF; Beth Israel Medical Center, New York, NY, USA. />Hu KS
Shourbaji RA
Ishihara D
Lin W
Kumar M
Blakaj DM
Harrison LB
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Źródło:
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Onkologie [Onkologie] 2013; Vol. 36 (3), pp. 83-6. Date of Electronic Publication: 2013 Feb 21.
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Typ publikacji:
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Controlled Clinical Trial; Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: Basel, New York, Karger.
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MeSH Terms:
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Carcinoma, Squamous Cell/*diagnostic imaging
Carcinoma, Squamous Cell/*radiotherapy
Laryngeal Neoplasms/*diagnostic imaging
Laryngeal Neoplasms/*radiotherapy
Radiation Injuries/*mortality
Radiotherapy, Conformal/*mortality
Tomography, X-Ray Computed/*statistics & numerical data
Adult ; Aged ; Aged, 80 and over ; Carcinoma, Squamous Cell/mortality ; Comorbidity ; Female ; Glottis/diagnostic imaging ; Humans ; Laryngeal Neoplasms/mortality ; Male ; Middle Aged ; New York/epidemiology ; Prevalence ; Prognosis ; Radiotherapy, Image-Guided/mortality ; Radiotherapy, Image-Guided/statistics & numerical data ; Risk Assessment ; Survival Analysis ; Survival Rate ; Tomography, X-Ray Computed/mortality ; Treatment Outcome
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Entry Date(s):
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Date Created: 20130315 Date Completed: 20130912 Latest Revision: 20161125
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Update Code:
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20240104
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DOI:
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10.1159/000348529
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PMID:
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23485994
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Purpose: Aim of this study was to evaluate the impact of computed tomography (CT)-based simulation and planning on early glottic cancer outcomes and toxicity.
Methods: This is a single-institution retrospective study of 253 patients with T1-2 glottic cancer who underwent radiation therapy (RT) from January 1998-2010. Group A (80%) underwent 2-dimensional RT (2DRT) and group B (20%) 3-dimensional RT (3DRT). 76% of patients in group A and 84% in group B had T1 cancer. The median dose and fraction size were 63 Gy and 2.25 Gy, respectively.
Results: With a median follow-up of 83, 93, and 30 months for the whole cohort, group A and B, respectively, the loco-regional control (LRC) was 97.6%. The rate of LRC for T1 disease was 99.5% and for T2 disease 91%. According to the RT modality, rates of LRC were 99.4 and 100% in groups A and B for T1, and 89.8 and 100% for T2. Long-term toxicity was negligible in both groups. Kaplan-Meier Curve showed the 5-year cause-specific survival to be 100%. Chi-square and multivariate analysis tests showed a significant relationship between CT simulation (3DRT) and LRC (p < 0.0001).
Conclusion: CT-based simulation and planning provided better LRC and less acute side effects compared to 2DRT.
(Copyright © 2013 S. Karger AG, Basel.)
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